Functional Group Tolerance of a Micellar on-DNA Suzuki–Miyaura Cross-Coupling Reaction for DNA-Encoded Library Design

Autor:	Michael J. Waring, Andrew Madin, James H. Hunter, Garry Pairaudeau, Andreas Brunschweiger, Harriet A. Stanway-Gordon, Marco Potowski
Rok vydání:	2021
Předmět:	Library design chemistry.chemical_compound chemistry Organic Chemistry Functional group DNA Ligands Combinatorial chemistry Micelles Coupling reaction
Zdroj:	The Journal of Organic Chemistry. 86:17930-17935
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.1c02259
Popis:	DNA-encoded libraries (DELs) offer great promise for the discovery of new ligands for proteins. Many current reactions used for DEL synthesis do not proceed efficiently over a wide range of substrates. Combining a diverse array of multicomponent reactions with micellar-promoted Suzuki-Miyaura cross-coupling provides a strategy for synthesizing highly diverse DELs with exceptionally high fidelity. These results demonstrate that the micellar Suzuki-Miyaura reaction has exceptional functional group tolerance and broad applicability.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d37797fba21a52440d18edaaf590ec5 https://doi.org/10.1021/acs.joc.1c02259 Zobrazit plný text záznamu