Granular cell basal cell carcinoma. Light microscopy, immunohistochemical and ultrastructural study
| Autor: | Claudio Ballestín, R. Gil, M. D. García Prats, Miguel Ángel Martínez-González, I. De Prada, M. López Carreira |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Cytoplasm Pathology medicine.medical_specialty Skin Neoplasms Biology Pathology and Forensic Medicine Granular cell Keratin Eosinophilic Microscopy medicine Humans Basal cell carcinoma Molecular Biology Aged chemistry.chemical_classification integumentary system Desmosomes Cell Biology General Medicine medicine.disease Immunohistochemistry Microscopy Electron chemistry Carcinoma Basal Cell Ultrastructure Keratins |
| Zdroj: | Virchows Archiv A Pathological Anatomy and Histopathology. 422:173-177 |
| ISSN: | 1432-2307 0174-7398 |
| DOI: | 10.1007/bf01607170 |
| Popis: | Granular cell basal cell carcinoma (BCC) is a rare histological variant of BCC. In this, the fifth reported case, a 67-year-old male with BCC located on the nose, light microscopy examination showed a tumour with the classical configuration of nodular BCC, in which most cells had finely granular eosinophilic cytoplasm. Ultrastructural observation showed numerous lysosome-like granules filling the cytoplasm of tumour cells, along with numerous well-formed pentalaminate desmosomes. Immunohistochemical profile (including positivity for keratins C 5.2 and AE 1 and for Leu-M1), together with the presence of cytoplasmic tonofilament bundles and desmosomes, are consistent with the proposed epithelial origin of granular cells in this tumour. |
| Databáze: | OpenAIRE |
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