Ontogeny of mouse vestibulo-ocular reflex following genetic or environmental alteration of gravity sensing
| Autor: | Mickael Bojados, Pierre-Paul Vidal, Marc Jamon, Mathieu Beraneck, Anne Le Seac'h |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Central Nervous System
Aging Mouse lcsh:Medicine Otology Mice 0302 clinical medicine Gravity Sensing lcsh:Science Otolith Vestibular system 0303 health sciences Multidisciplinary Anatomy Reflex Vestibulo-Ocular Animal Models Sensory Systems medicine.anatomical_structure Medicine Sensory Perception Research Article Gravity (chemistry) Neurophysiology Otolithic membrane Hypergravity Biology Environment 03 medical and health sciences Otolithic Membrane Model Organisms Developmental Neuroscience medicine Genetics otorhinolaryngologic diseases Animals 030304 developmental biology Motor Systems lcsh:R Mice Inbred C57BL Otorhinolaryngology Reflex lcsh:Q Neural Circuit Formation sense organs Vestibulo–ocular reflex Gene Function Sensory Deprivation 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS ONE, Vol 7, Iss 7, p e40414 (2012) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | The vestibular organs consist of complementary sensors: the semicircular canals detect rotations while the otoliths detect linear accelerations, including the constant pull of gravity. Several fundamental questions remain on how the vestibular system would develop and/or adapt to prolonged changes in gravity such as during long-term space journey. How do vestibular reflexes develop if the appropriate assembly of otoliths and semi-circular canals is perturbed? The aim of present work was to evaluate the role of gravity sensing during ontogeny of the vestibular system. In otoconia-deficient mice (ied), gravity cannot be sensed and therefore maculo-ocular reflexes (MOR) were absent. While canals-related reflexes were present, the ied deficit also led to the abnormal spatial tuning of the horizontal angular canal-related VOR. To identify putative otolith-related critical periods, normal C57Bl/6J mice were subjected to 2G hypergravity by chronic centrifugation during different periods of development or adulthood (Adult-HG) and compared to non-centrifuged (control) C57Bl/6J mice. Mice exposed to hypergravity during development had completely normal vestibulo-ocular reflexes 6 months after end of centrifugation. Adult-HG mice all displayed major abnormalities in maculo-ocular reflexe one month after return to normal gravity. During the next 5 months, adaptation to normal gravity occurred in half of the individuals. In summary, genetic suppression of gravity sensing indicated that otolith-related signals might be necessary to ensure proper functioning of canal-related vestibular reflexes. On the other hand, exposure to hypergravity during development was not sufficient to modify durably motor behaviour. Hence, 2G centrifugation during development revealed no otolith-specific critical period. |
| Databáze: | OpenAIRE |
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