Facile and inexpensive fabrication of zinc oxide based bio-surfaces for C-reactive protein detection
| Autor: | Richard Luxton, Martina Piano, Janice Kiely, Lu Cao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Fabrication
Materials science Sonication lcsh:Medicine chemistry.chemical_element Nanoparticle Biosensing Techniques 02 engineering and technology Zinc 010402 general chemistry 01 natural sciences Article chemistry.chemical_compound Polyethylene terephthalate biosenor zinc oxide rapid nanomaterials lcsh:Science Detection limit Multidisciplinary Polyethylene Terephthalates lcsh:R technology industry and agriculture 021001 nanoscience & nanotechnology 0104 chemical sciences Dielectric spectroscopy C-Reactive Protein chemistry Chemical engineering lcsh:Q Institute of Bio-Sensing Technology Centre for Research in Biosciences Zinc Oxide 0210 nano-technology Biosensor |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) |
| ISSN: | 2045-2322 |
| Popis: | The paper reports a biosensor formed from antibody coated ZnO nano-crystals which has been prepared using a rapid and inexpensive fabrication method which utilises colloidal dispersion enhanced using sonication. This technique was used to prepare highly ordered and uniform nano-crystalline sensor surfaces on polyethylene terephthalate (PET) using 0.5%, 1% and 5% concentrations of zinc oxide nano-crystal suspensions. Impedance spectroscopy was employed to interrogate the sensor surfaces and confirmed high reproducibility of the fabrication process. Changes in impedance values, at a frequency of 138 Hz, were used to establish dose dependent responses for C-reactive protein (CRP) antigen. A limit of detection of less than 1 ng/ml was demonstrated for nano-surfaces fabricated from concentrations of 1% ZnO. |
| Databáze: | OpenAIRE |
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