Colon adenocarcinoma with dome-like phenotype: characteristic endoscopic ultrasonography (EUS) findings
| Autor: | Shiro Hayashi, Masashi Yamamoto, Hirotsugu Saiki, Katsumi Yamamoto, Shiro Adachi, Hisashi Kondo, Aisa Sakamoto, Takamichi Komori, Wataru Takagi, Shunji Morita, Yuriko Otake, Tsutomu Nishida, Kei Takahashi, Makiko Urabe, Masami Inada, Takahiro Amano, Sachiko Nakajima |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test business.industry Sigmoid colon Colonoscopy medicine.disease Article digestive system diseases Chromoendoscopy Staining Lesion medicine.anatomical_structure Sigmoidectomy Biopsy medicine Adenocarcinoma Pharmacology (medical) lcsh:Diseases of the digestive system. Gastroenterology medicine.symptom lcsh:RC799-869 business |
| Zdroj: | Endoscopy International Open, Vol 03, Iss 04, Pp E359-E362 (2015) Endoscopy International Open |
| ISSN: | 2196-9736 2364-3722 |
| Popis: | An 80-year-old man underwent colonoscopy for proctorrhagia. Conventional white-light imaging showed a superficially flat and elevated lesion that appeared to be a submucosal tumor of the sigmoid colon. Chromoendoscopy with Indigo Carmine showed that the margin of the tumor was covered with normal epithelium but that there was a slight depression on its surface. Magnification endoscopy with Crystal Violet staining revealed the amorphous surface structure of the depressed lesion, but the surrounding mucosa showed a normal pit pattern. Endoscopic ultrasonography demonstrated that a hypoechoic mass was located in the submucosal layer, and a biopsy specimen obtained from the surface of the lesion showed evidence of adenocarcinoma. We then performed sigmoidectomy on the patient. Immunohistochemically, the tumor cells were positive for two mismatch repair proteins (MLH1 and MSH2), but in situ hybridization revealed that the specimen was negative for the Epstein – Barr virus. We finally diagnosed the lesion as adenocarcinoma with a dome-like phenotype of the sigmoid colon. |
| Databáze: | OpenAIRE |
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