Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction
| Autor: | Xu‐zhao Li, Shuai‐nan Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Herbal Medicine Population medicine.disease_cause Autoimmunity Arthritis Rheumatoid Chondroprotection 03 medical and health sciences 0302 clinical medicine Drug likeness medicine Humans Cartilage destruction education Pharmacology 0303 health sciences education.field_of_study Plants Medicinal Traditional medicine business.industry Cheminformatics 030302 biochemistry & molecular biology Middle Aged medicine.disease 030220 oncology & carcinogenesis Rheumatoid arthritis Chronic Disease Female business |
| Zdroj: | Phytotherapy Research. 34:51-66 |
| ISSN: | 1099-1573 0951-418X |
| Popis: | Rheumatoid arthritis (RA) is a systemic disease characterized by autoimmunity, joint inflammation, and cartilage destruction, which affects 0.5-1% of the population. Many compounds from herbal medicines show the potentials to treat RA. On this basis, the compounds with good pharmacokinetic behaviors and drug-likeness properties will be further studied and developed. Therefore, the herbal compounds with anti-RA activities were reviewed in this paper, and the cheminformatics tools were used to predict their drug-likeness properties and pharmacokinetic parameters. A total of 90 herbal compounds were analyzed, which were reported to be effective on RA models through anti-inflammation, chondroprotection, immunoregulation, antiangiogenesis, and antioxidation. Most of the herbal compounds have good drug-likeness properties. Most of the compounds can be an alternative and valuable source for anti-RA drug discovery. |
| Databáze: | OpenAIRE |
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