Central Precocious Puberty as a Complication of Therapy with Adrenocorticotropin (ACTH) and an Aromatase Inhibitor for Refractory Nephrotic Syndrome
| Autor: | Lawrence S. Milner, Robert C. Gensure, Julie Nicoletta, Sungeeta Agrawal, Abdollah Sadeghi-Nejad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
endocrine system medicine.drug_class medicine.medical_treatment Central precocious puberty Case Report urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Refractory Internal medicine medicine 030304 developmental biology 0303 health sciences 030219 obstetrics & reproductive medicine Aromatase inhibitor Proteinuria business.industry lcsh:RJ1-570 lcsh:Pediatrics General Medicine Immunotherapy medicine.disease Peripheral Endocrinology medicine.symptom Complication business Nephrotic syndrome hormones hormone substitutes and hormone antagonists |
| Zdroj: | Case Reports in Pediatrics Case Reports in Pediatrics, Vol 2019 (2019) |
| ISSN: | 2090-6811 2090-6803 |
| Popis: | Glucocorticoids are typically prescribed for the treatment of idiopathic nephrotic syndrome of childhood. In selected patients with refractory focal segmental glomuerulosclerosis (FSGS), adrenocorticotropin (ACTH) can be used to induce remission and decrease the progression of the disease. We report a 6 8/12-year-old girl with recurrent proteinuria, resistant to standard immunotherapy. She underwent related renal transplant but again developed proteinuria and was started on ACTH. She subsequently developed peripheral precocious puberty (PPP), presumably from peripheral aromatization of adrenal androgens. She was started on an aromatase inhibitor, and her ACTH dose was slowly decreased. She then developed central precocious puberty (CPP). We hypothesize that treatment of her peripheral precocious puberty with an aromatase inhibitor may have triggered central precocious puberty. |
| Databáze: | OpenAIRE |
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