Molecular Changes Underlying Genistein Treatment of Wound Healing: A Review
| Autor: | Petra Mitrengová, Matúš Čoma, Veronika Lachová, Petr Gál |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Agonist Selective Estrogen Receptor Modulators skin wound QH301-705.5 medicine.drug_class Genistein Phytoestrogens Pharmacology Regenerative Medicine Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Poor wound healing Animals Humans Biology (General) Molecular Biology Skin repair Wound Healing business.industry Regeneration (biology) Antagonist General Medicine SERM 030104 developmental biology chemistry Selective estrogen receptor modulator repair regeneration 030220 oncology & carcinogenesis phytoestrogen business Wound healing hormones hormone substitutes and hormone antagonists isoflavone Signal Transduction |
| Zdroj: | Current Issues in Molecular Biology, Vol 43, Iss 11, Pp 127-141 (2021) |
| ISSN: | 1467-3045 |
| Popis: | Estrogen deprivation is one of the major factors responsible for many age-related processes including poor wound healing in postmenopausal women. However, the reported side-effects of estrogen replacement therapy (ERT) have precluded broad clinical administration. Therefore, selective estrogen receptor modulators (SERMs) have been developed to overcome the detrimental side effects of ERT on breast and/or uterine tissues. The use of natural products isolated from plants (e.g., soy) may represent a promising source of biologically active compounds (e.g., genistein) as efficient alternatives to conventional treatment. Genistein as natural SERM has the unique ability to selectively act as agonist or antagonist in a tissue-specific manner, i.e., it improves skin repair and simultaneously exerts anti-cancer and chemopreventive properties. Hence, we present here a wound healing phases-based review of the most studied naturally occurring SERM. |
| Databáze: | OpenAIRE |
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