T cells produce an antigen-binding factor with in vivo activity analogous to IgE antibody
| Autor: | R W Rosenstein, Wlodzimierz Ptak, Philip W. Askenase |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1983 |
| Předmět: |
Male
T cell T-Lymphocytes Immunology Vascular permeability Picryl Chloride Immunoglobulin E Binding Competitive Epitope Chromatography Affinity Epitopes Mice medicine Suppressor Factors Immunologic Immunology and Allergy Cytotoxic T cell Animals Hypersensitivity Delayed Mast Cells Lymphokines biology Chemistry Lymphokine Immunization Passive Oxazolone Articles Mast cell Molecular biology Mice Mutant Strains Antibodies Anti-Idiotypic Mice Inbred C57BL medicine.anatomical_structure biology.protein Mice Inbred CBA Binding Sites Antibody Antibody |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | T cell-dependent activation of resident tissue mast cells is required for the elicitation of delayed-type hypersensitivity skin reactions in mice. A T cell-derived antigen-binding factor that transfers the ability to elicit an immediate hypersensitivity-like skin reaction is described and compared with a hybridoma IgE antibody. Both the T cell factor and IgE mediate reactions with increased vascular permeability and both are mast cell dependent, as they are inactive in two different types of mast cell deficient mice (W/Wv and Sl/Sld). The T cell factor was distinguished from IgE by affinity chromatography using specific anti-IgE and anti-factor antibodies and by a shorter duration of passive sensitization. The T cell factor is a suitable candidate for participation in the mechanism by which T cells activate mast cells in delayed-type hypersensitivity. |
| Databáze: | OpenAIRE |
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