A novel protocol to reduce bleeding associated with alteplase treatment of HVAD pump thrombosis
| Autor: | Deane E. Smith, Amy Emmarco, Nader Moazami, Tyler C Lewis, Alex Reyentovich, Claudia Gidea |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Biomedical Engineering Less invasive Medicine (miscellaneous) Bioengineering 030204 cardiovascular system & hematology Biomaterials 03 medical and health sciences 0302 clinical medicine Internal medicine Fibrinolysis medicine Humans Significant risk Pump thrombosis Retrospective Studies Intracerebral hemorrhage Heart Failure business.industry Optimal treatment Thrombosis General Medicine medicine.disease Prothrombin complex concentrate 030228 respiratory system Tissue Plasminogen Activator Cardiology Heart-Assist Devices Complication business medicine.drug |
| Zdroj: | The International journal of artificial organs. 45(2) |
| ISSN: | 1724-6040 |
| Popis: | Pump thrombosis remains a feared complication for patients implanted with durable left ventricular assist devices. Optimal treatment is unknown, but consists of either pharmacologic fibrinolysis or surgical pump exchange. Fibrinolysis is less invasive, but carries a significant risk of intracerebral hemorrhage. We present four cases of LVAD pump thrombosis successfully treated with a novel protocol that consists of low-dose four-factor prothrombin complex concentrate to reverse baseline INR elevation prior to alteplase administration to minimize the risk for intracerebral hemorrhage. |
| Databáze: | OpenAIRE |
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