The association of uncoupling protein 2 (UCP2) exon 8 insertion/deletion polymorphism and ECG derived QRS duration: A cross-sectional study in an Australian rural population
| Autor: | Brett D. Hambly, Yuling Zhou, Craig S. McLachlan, Herbert F. Jelinek, Yvonne Yin Leng Lee |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Rural Population medicine.medical_specialty Genotype Heart Diseases Cross-sectional study Population 030204 cardiovascular system & hematology Polymerase Chain Reaction QT interval Electrocardiography 03 medical and health sciences QRS complex 0302 clinical medicine Heart Rate Internal medicine Cardiac conduction Heart rate medicine Humans Uncoupling Protein 2 cardiovascular diseases 030212 general & internal medicine education Aged Retrospective Studies education.field_of_study Polymorphism Genetic medicine.diagnostic_test business.industry Incidence DNA Exons Cross-Sectional Studies Cardiology Female New South Wales Cardiology and Cardiovascular Medicine business |
| Zdroj: | International Journal of Cardiology. 228:507-510 |
| ISSN: | 0167-5273 |
| Popis: | Background Associations between inherited mitochondrial disease and cardiac conduction have been previously described. However, there are no available studies exploring the mitochondrial uncoupling protein 2 gene (UCP2) insertion/deletion (I/D) polymorphisms interaction on cardiac electrical conduction. Our aim was to determine if ECG-derived QRS duration is associated with UCP2 DD genotype in a cross-sectional Australian aging rural population. Methods A retrospective study design utilizing a rural health diabetic screening clinic data-base containing observational data from September 2011 to September 2014. Inclusion criteria included were having ECG parameters such as QRS duration measures and a DNA sample within the same subject. Genomic DNA was extracted and subjects were genotyped for the 45-bp I/D polymorphism in the 3′-untranslated region of UCP2. Results 281 individuals were available for analysis. On the basis of QRS duration >140ms we found an increased percentage of our population with DD homozygotes, compared to ID heterozygotes and II homozygotes (p=0.047). For other ECG parameters; mean PQ duration, QTc across UCP2 genotypes was not significant (p=NS). QTc using a cut-off >440ms in contingency table analysis revealed no significant differences across UCP2 I/D genotypes. Mean QT dispersion (QTd) was paradoxically less in the UCP2 DD genotype compared to UCP2 II subgroup (p=0.034). Discussion We have demonstrated an association between increasing ECG-derived QRS duration >140ms and the UCP2 DD polymorphism. The lack of association with ECG derived QTd and UCP2 DD may suggest that gene-related QRS duration prolongation is independent of cardiac hypertrophy. |
| Databáze: | OpenAIRE |
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