Poor Survival and Differential Impact of Genetic Features of Black Patients with Acute Myeloid Leukemia
| Autor: | Bayard L. Powell, Bhavana Bhatnagar, Alice S. Mims, Isaiah Boateng, Deedra Nicolet, Richard Stone, James S. Blachly, Shelley Orwick, Jessica Kohlschmidt, Ann-Kathrin Eisfeld, Albert de la Chapelle, Sophia E. Maharry, Jonathan E. Kolitz, Ramiro Garzon, Andrew J. Carroll, John C. Byrd, James L. Fisher, Krzysztof Mrózek, Electra D. Paskett, Brian Giacopelli, Qiuhong Zhao, Christopher C. Oakes, Christopher J. Walker |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Patient demographics MEDLINE Disease Article 03 medical and health sciences 0302 clinical medicine Internal medicine Surveillance Epidemiology and End Results Ethnicity Medicine Humans Socioeconomic status Differential impact Retrospective Studies business.industry Myeloid leukemia United States Clinical trial Black or African American Leukemia Myeloid Acute 030104 developmental biology Treatment Outcome 030220 oncology & carcinogenesis business |
| Zdroj: | Cancer Discov |
| Popis: | Clinical outcome of patients with acute myeloid leukemia (AML) is associated with cytogenetic and molecular factors and patient demographics (e.g., age and race). We compared survival of 25,523 non-Hispanic Black and White adults with AML using Surveillance Epidemiology and End Results (SEER) Program data and performed mutational profiling of 1,339 patients with AML treated on frontline Alliance for Clinical Trials in Oncology (Alliance) protocols. Black patients had shorter survival than White patients, both in SEER and in the setting of Alliance clinical trials. The disparity was especially pronounced in Black patients Significance: We show that young Black patients have not benefited as much as White patients from recent progress in AML treatment in the United States. Our data suggest that both socioeconomic factors and differences in disease biology contribute to the survival disparity and need to be urgently addressed. See related commentary by Vyas, p. 540. This article is highlighted in the In This Issue feature, p. 521 |
| Databáze: | OpenAIRE |
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