Current treatment landscape for oligometastatic non-small cell lung cancer
| Autor: | Javier, Garde-Noguera, Margarita, Martín-Martín, Andres, Obeso, Miriam, López-Mata, Inigo Royo, Crespo, Lira, Pelari-Mici, O, Juan Vidal, Xabier, Mielgo-Rubio, Juan Carlos, Trujillo-Reyes, Felipe, Couñago |
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| Přispěvatelé: | Institut Català de la Salut, [Garde-Noguera J] Department of Medical Oncology, Hospital Arnau de Vilanova, Valencia, Spain. [Martín-Martín M, Pelari-Mici L] Department of Radiation Oncology, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Obeso A] Department of Thoracic Surgery, Hospital Clínico Universitario de Santiago de Compostela, Vigo, Spain. [López-Mata M] Department of Radiation Oncology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain. [Crespo IR] Servei de Cirurgia Toràcica, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Oncology
Medicaments antineoplàstics - Ús terapèutic acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos [COMPUESTOS QUÍMICOS Y DROGAS] Other subheadings::/therapy [Other subheadings] Extirpació (Cirurgia) Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms::Bronchial Neoplasms::Carcinoma Bronchogenic::Carcinoma Non-Small-Cell Lung [DISEASES] Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents [CHEMICALS AND DRUGS] neoplasias::neoplasias por localización::neoplasias torácicas::neoplasias del tracto respiratorio::neoplasias pulmonares::neoplasias de los bronquios::carcinoma broncogénico::carcinoma de pulmón de células no pequeñas [ENFERMEDADES] Surgical Procedures Operative::Ablation Techniques [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] Pulmons - Càncer - Tractament intervenciones quirúrgicas::técnicas ablativas [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Otros calificadores::/terapia [Otros calificadores] |
| Zdroj: | Scientia |
| Popis: | Non-small cell lung cancer; Oligometastatic Cáncer de pulmón de células no pequeñas; Oligometastásico Càncer de pulmó de cèl·lules no petites; Oligometastàtic The management of patients with advanced non-small cell lung carcinoma (NSCLC) has undergone major changes in recent years. On the one hand, improved sensitivity of diagnostic tests, both radiological and endoscopic, has altered the way patients are staged. On the other hand, the arrival of new drugs with antitumoral activity, such as targeted therapies or immunotherapy, has changed the prognosis of patients, improving disease control and prolonging survival. Finally, the development of radiotherapy and surgical and interventional radiology techniques means that radical ablative treatments can be performed on metastases in any location in the body. All of these advances have impacted the treatment of patients with advanced lung cancer, especially in a subgroup of these patients in which all of these treatment modalities converge. This poses a challenge for physicians who must decide upon the best treatment strategy for each patient, without solid evidence for one optimal mode of treatment in this patient population. The aim of this article is to review, from a practical and multidisciplinary perspective, published evidence on the management of oligometastatic NSCLC patients. We evaluate the different alternatives for radical ablative treatments, the role of primary tumor resection or radiation, the impact of systemic treatments, and the therapeutic sequence. In short, the present document aims to provide clinicians with a practical guide for the treatment of oligometastatic patients in routine clinical practice. |
| Databáze: | OpenAIRE |
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