Plasma 25-hydroxyvitamin D and not 1,25-dihydroxyvitamin D is associated with parathyroid adenoma secretion in primary hyperparathyroidisn: a cross-sectional study
| Autor: | Peer Christiansen, Lis Mosekilde, Flemming Melsen, Lene Heickendorff, Bjarke Moosgaard, P. Vestergaard |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Adenoma
Adult Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Parathyroid hormone vitamin D deficiency Parathyroid Glands Endocrinology Internal medicine medicine Vitamin D and neurology Humans Vitamin D Aged Parathyroid adenoma Aged 80 and over Hyperparathyroidism Parathyroid neoplasm Chemistry Organ Size General Medicine Parathyroid chief cell Middle Aged Hyperparathyroidism Primary Vitamin D Deficiency medicine.disease Cross-Sectional Studies Parathyroid Neoplasms Parathyroid Hormone Female Primary hyperparathyroidism |
| Zdroj: | Moosgaard, B, Vestergaard, P, Heickendorff, L, Melsen, F, Christiansen, P M & Mosekilde, L 2006, ' Plasma 25-hydroxyvitamin D and not 1,25-dihydroxyvitamin D is associated with parathyroid adenoma secretion in primary hyperparathyroidisn: a cross-sectional study ', European Journal of Endocrinology, vol. 155, no. 2, pp. 237-44 . |
| Popis: | Background: Primary hyperparathyroidism (PHPT) is associated with reduced plasma 25-hydroxyvitamin D (P-25OHD) and usually increased plasma 1α,25-dihydroxyvitamin D (P-1,25(OH)2D). Parathyroid tissue expresses the vitamin D receptor and it is thought that circulating 1,25(OH)2D participate in the regulation of parathyroid cell proliferation, differentiation and secretion. Aim: To investigate the relations between circulating levels of 1,25(OH)2D and 25OHD respectively and parathyroid adenoma weight (AW), plasma-parathyroid hormone (P-PTH) and PTH secretion expressed as P-PTH/AW. Design: Cross-sectional study. Material: One hundred and seventy-one consecutive hypercalcaemic caucasian patients aged 19–87 years (median 63, 84% females) with surgically proven parathyroid adenoma. Results: A weak positive correlation was found between P-25OHD and P-1,25(OH)2D (r = 0.24, P < 0.005). AW depended on sex and body mass index. Following adjustment, it was correlated positively to P-PTH, calcium (Ca) and alkaline phosphatase (AP) and inversely to plasma phosphate in a multiple regression model. AW was not associated with vitamin D metabolites. Preoperative P-PTH correlated positively to plasma levels of Ca and AP, but inversely to phosphate and 25OHD (P < 0.001) levels. P-PTH was not associated with P-1,25(OH)2D (P = 0.65). The P-PTH:AW ratio correlated inversely to P-25OHD (P < 0.05), but showed no relations to plasma levels of Ca, phosphate or 1,25(OH)2D (P = 0.22). Conclusion: In this material, low levels of 25OHD were related to higher levels of P-PTH and higher PTH:AW ratios in patients with PHPT suggesting that vitamin D deficiency increase PTH secretion activity. Neither PTH secretion nor AW was associated with circulating levels of 1,25(OH)2D. |
| Databáze: | OpenAIRE |
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