Promote Recurrent Aphthous Ulcer Healing with Low Dose Prednisolone Bilayer Mucoadhesive Buccal Film
| Autor: | Ming Ming Wen, Ragwa M. Farid |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Recurrent aphthous ulcer Prednisolone Lipid Bilayers Pharmaceutical Science Dentistry 02 engineering and technology Acetates Pharmacology 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo medicine Animals Humans Oral mucosa Ulcer Wound Healing Dose-Response Relationship Drug business.industry Chemistry Bilayer Administration Buccal Buccal administration 021001 nanoscience & nanotechnology Healthy Volunteers Gellan gum medicine.anatomical_structure Prednisolone Sodium Phosphate Female Stomatitis Aphthous Rabbits 0210 nano-technology business medicine.drug |
| Zdroj: | Current Drug Delivery. 14:123-135 |
| ISSN: | 1567-2018 |
| DOI: | 10.2174/1567201813666160316122548 |
| Popis: | Background Recurrent aphthous ulcer (RAU) is one of the most common ulcerative diseases of the oral mucosa which is recurrent, painful and slow to heal. Treatment is primarily for pain relief and promotion of healing to shorten the disease duration or reduce the rate of recurrence. Objective Development of a new design of topical buccal bilayer mucoadhesive films containing sodium alginate and gellan gum loaded with low dose of 1 mg prednisolone sodium phosphate to reduce the treatment period and decrease side effects of systemic treatment. Methods Films were prepared by solvent casting technique and evaluated to ensure optimum film characteristics, and in vivo efficiency. Results The bilayer films were thin, flexible with good water uptake, mucoadhesive and mechanical properties. In vitro drug release was sustained and showed anomalous non-Fickian kinetics. SEM confirmed the development of bilayer formation. Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimetery indicated no chemical interaction between the layers. In vivo study in rabbits with induced oral ulceration showed complete ulcer healing within 4-5 days by once daily treatment of the studied film. Histological examination indicated no inflammation on treatment sites compared to inflamed tissue on the control sites. Conclusion The results suggested that buccal application of the developed bilayer mucoadhesive films loaded with only 1mg of prednisolone provided mucoadhesive and convenient application and was able to promote RAU healing with shorter treatment duration. |
| Databáze: | OpenAIRE |
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