Initiating Antiretroviral Treatment Early in Infancy Has Long-term Benefits on the Human Immunodeficiency Virus Reservoir in Late Childhood and Adolescence
| Autor: | Mariama Sadjo Diallo, Albert Faye, Jérome Lechenadec, Véronique Avettand-Fenoel, Stéphane Blanche, Florence Buseyne, Pierre Frange, Anrs-Ep Cleac Study, Josiane Warszawski, Adeline Melard, Brigitte Autran, Catherine Dollfus, Marine Fillion, Assia Samri, Kahina Amokrane |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Cart medicine.medical_specialty Adolescent T cell 030106 microbiology Human immunodeficiency virus (HIV) HIV Infections Viremia Human leukocyte antigen medicine.disease_cause Peripheral blood mononuclear cell 03 medical and health sciences 0302 clinical medicine Antiretroviral Therapy Highly Active Internal medicine Antiretroviral treatment Humans Medicine 030212 general & internal medicine Child business.industry virus diseases Viral Load medicine.disease 3. Good health Infectious Diseases medicine.anatomical_structure DNA Viral HIV-1 Leukocytes Mononuclear business Ex vivo |
| Zdroj: | Clinical Infectious Diseases. 73:e4214-e4222 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | BackgroundEarly combined antiretroviral therapy (cART) limits the total HIV-DNA load in children. However, data on its impact in older children and adolescents remain scarce. This study compares HIV reservoirs in children (5–12 years) and adolescents (13–17 years) who started cART 2 years (late [L-] group).MethodsThe ANRS-EP59-CLEAC study prospectively enrolled 76 patients perinatally infected with HIV-1 who reached HIV-RNA ResultsTotal HIV-DNA levels were lower in early- versus late-treated patients (children: 2.14 vs 2.87 log copies/million PBMCs; adolescents: 2.25 vs 2.74 log; P < .0001 for both). Low reservoir was independently associated with treatment precocity, protective HLA, and low cumulative viremia since cART initiation. The 60 participants with undetectable integrated HIV-DNA started cART earlier than other patients (4 vs 54 months; P = .03). In those with sustained virological control, transitional and effector memory CD4+ T cells were less infected in the E-group than in the L-group (P = .03 and .02, respectively). Viral inducibility of reservoir cells after normalization to HIV-DNA levels was similar between groups.ConclusionsEarly cART results in a smaller blood HIV reservoir until adolescence, but all tested participants had an inducible reservoir. This deserves cautious consideration for HIV remission strategies. |
| Databáze: | OpenAIRE |
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