The amygdala is part of the behavioural reinforcement system modulating long-term potentiation in rat hippocampus
| Autor: | W. Almaguer-Melian, Jorge A. Bergado, L Martínez-Martí, Julietta U. Frey |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Time Factors Long-Term Potentiation Central nervous system Drinking Stimulus (physiology) Neurotransmission Hippocampus Amygdala Rats Sprague-Dawley medicine Animals Anesthetics Local Analysis of Variance Behavior Animal Water Deprivation General Neuroscience Dentate gyrus Excitatory Postsynaptic Potentials Lidocaine Long-term potentiation Electric Stimulation Rats medicine.anatomical_structure nervous system Synaptic plasticity Psychology Reinforcement Psychology Neuroscience Basolateral amygdala |
| Zdroj: | Neuroscience. 119:319-322 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/s0306-4522(02)00867-9 |
| Popis: | Long-term potentiation (LTP) in the dentate gyrus can be modulated and prolonged by emotional/motivational influences when concurrently activated. A similar effect on LTP can be obtained by stimulating the amygdala, suggesting that this limbic structure might be part of the neural system involved in behavioural reinforcement. To confirm this we have performed a series of experiments in which the basolateral amygdala was either temporary inactivated by injection of lidocaine or permanently lesioned electrolytically. Both manipulations completely blocked the reinforcing effect of a motivational stimulus (drinking after 24-h deprivation) on LTP at the perforant pathway-dentate gyrus synapses, whilst leaving intact the non-reinforced potentiation. These results demonstrate that the basolateral amygdala is a key structure within the system involved in the modulatory interaction between the affective status of the animal and the mechanisms of functional plasticity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect