Predictors of Esophageal Stricture Formation Post Endoscopic Mucosal Resection
| Autor: | Christianne Wolfsen, Cynthia Rizk, Bashar J. Qumseya, Timothy A. Woodward, David J. Cangemi, Massimo Raimondo, Abraham M. Panossian, Herbert C. Wolfsen, Michael B. Wallace |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Complications Barrett esophagus medicine.diagnostic_test business.industry Gastroenterology Medicine (miscellaneous) Endoscopic mucosal resection Endoscopy Odds ratio medicine.disease Dysphagia Confidence interval Surgery Lesion Esophageal stenosis Esophageal stricture Medicine Radiology Nuclear Medicine and imaging Original Article medicine.symptom business Complication |
| Zdroj: | Clinical Endoscopy |
| ISSN: | 2234-2443 2234-2400 |
| Popis: | Background/aims Stricture formation is a common complication after endoscopic mucosal resection. Predictors of stricture formation have not been well studied. Methods We conducted a retrospective, observational, descriptive study by using a prospective endoscopic mucosal resection database in a tertiary referral center. For each patient, we extracted the age, sex, lesion size, use of ablative therapy, and detection of esophageal strictures. The primary outcome was the presence of esophageal stricture at follow-up. Multivariate logistic regression was used to analyze the association between the primary outcome and predictors. Results Of 136 patients, 27% (n=37) had esophageal strictures. Thirty-two percent (n=44) needed endoscopic dilation to relieve dysphagia (median, 2; range, 1 to 8). Multivariate logistic regression analysis showed that the size of the lesion excised is associated with increased odds of having a stricture (odds ratio, 1.6; 95% confidence interval, 1.1 to 2.3; p=0.01), when controlling for age, sex, and ablative modalities. Similarly, the number of lesions removed in the index procedure was associated with increased odds of developing a stricture (odds ratio, 2.3; 95% confidence interval, 1.3 to 4.2; p=0.007). Conclusions Stricture formation after esophageal endoscopic mucosal resection is common. Risk factors for stricture formation include large mucosal resections and the resection of multiple lesions on the initial procedure. |
| Databáze: | OpenAIRE |
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