State-dependent representations of mixtures by the olfactory bulb
| Autor: | Janine Kristin Reinert, Aliya Mari Adefuin, Izumi Fukunaga, Sander Lindeman |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Olfactory system
Neurons General Immunology and Microbiology Sensory processing General Neuroscience medicine.medical_treatment Sensory system General Medicine Olfaction Olfactory Pathways Stimulus (physiology) Olfactory Perception Olfactory Bulb General Biochemistry Genetics and Molecular Biology Olfactory Receptor Neurons Olfactory bulb Smell Mice Piriform cortex Odorants medicine Animals Neuroscience Transduction (physiology) Mathematics |
| Zdroj: | eLife. 11 |
| ISSN: | 2050-084X |
| Popis: | Sensory systems are often tasked to analyse complex signals from the environment, separating relevant from irrelevant parts. This process of decomposing signals is challenging when a mixture of signals does not equal the sum of its parts, leading to an unpredictable corruption of signal patterns. In olfaction, nonlinear summation is prevalent at various stages of sensory processing. Here, we investigate how the olfactory system deals with binary mixtures of odours under different brain states, using two-photon imaging of olfactory bulb (OB) output neurons. Unlike previous studies using anaesthetised animals, we found that mixture summation is more linear in the early phase of evoked responses in awake, head-fixed mice performing an odour detection task, due to dampened responses. Despite this, and responses being more variable, decoding analyses indicated that the data from behaving mice was well discriminable. Curiously, the time course of decoding accuracy did not correlate strictly with the linearity of summation. Further, a comparison with naïve mice indicated that learning to accurately perform the mixture detection task is not accompanied by more linear mixture summation. Finally, using a simulation, we demonstrate that, while saturating sublinearity tends to degrade the discriminability, the extent of the impairment may depend on other factors, including pattern decorrelation. Altogether, our results demonstrate that the mixture representation in the primary olfactory area is state-dependent, but the analytical perception may not strictly correlate with linearity in summation. |
| Databáze: | OpenAIRE |
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