Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2

Autor:	Pengxuan Ren, Changyue Yu, Ruxue Zhang, Tianqing Nie, Qiaoyu Hu, Hui Li, Xianglei Zhang, Xueyuan Zhang, Lu Liu, Wenhao Dai, Jian Li, Yechun Xu, Haixia Su, Leike Zhang, Hong Liu, Shiwei Li, Fang Bai
Rok vydání:	2023
Předmět:	Pharmacology History Polymers and Plastics Organic Chemistry Drug Discovery General Medicine Business and International Management Industrial and Manufacturing Engineering
Zdroj:	European Journal of Medicinal Chemistry. 249:115129
ISSN:	0223-5234
DOI:	10.1016/j.ejmech.2023.115129
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1f0854840c77b51e4487879ecb568c https://doi.org/10.1016/j.ejmech.2023.115129 Zobrazit plný text záznamu Full Text from ScienceDirect