The CD14 C-260T single nucleotide polymorphism (SNP) modulates monocyte/macrophage activation in treated HIV-infected individuals

Autor: Noor Kamila Abdullah, Muhamad Yazli Yuhana, Sharon R Lewin, Yong Yean Kong, Reena Rajasuriar, Reshika Nadarajah, Sasheela Ponampalavanar, Adeeba Kamarulzaman, Tim Spelman
Rok vydání: 2015
Předmět:
Adult
Male
medicine.medical_specialty
Population
Lipopolysaccharide Receptors
HIV Infections
Lipopolysaccharide
Single-nucleotide polymorphism
Biology
Systemic inflammation
Carotid Intima-Media Thickness
Polymorphism
Single Nucleotide
Gastroenterology
Monocytes
General Biochemistry
Genetics and Molecular Biology
C-reactive protein
Cohort Studies
Soluble CD14
Risk Factors
Internal medicine
Carotid intima media thickness
medicine
Humans
SNP
Genetic Predisposition to Disease
cardiovascular diseases
education
Medicine(all)
Inflammation
education.field_of_study
Monocyte activation
Framingham Risk Score
Biochemistry
Genetics and Molecular Biology(all)
Soluble CD163
Research
HIV
General Medicine
Macrophage Activation
Atherosclerosis
CD12 C-260T
Intima-media thickness
Multivariate Analysis
Cohort
Immunology
biology.protein
Female
medicine.symptom
Biomarkers
Zdroj: Journal of Translational Medicine
ISSN: 1479-5876
Popis: Background HIV-infected individuals have an increased risk of cardiovascular disease (CVD). T-allele carriers of the CD14 C-260T single-nucleotide polymorphism (SNP) have reported increased expression of the LPS-binding receptor, CD14 and inflammation in the general population. Our aim was to explore the relationship of this SNP with monocyte/macrophage activation and inflammation and its association with sub-clinical atherosclerosis in HIV-infected individuals. Methods Patients with no pre-existing CVD risk factors on suppressive antiretroviral therapy were recruited from University Malaya Medical Centre, Malaysia (n = 84). The CD14 C-260T and TLR4 SNPs, Asp299Gly and Thr399Ile were genotyped and soluble(s) CD14 and sCD163 and high-sensitivity C-reactive protein, hsCRP were measured in plasma. Subclinical atherosclerosis was assessed by measuring carotid intima media thickness (cIMT). The association between CD14 C-260T SNP carriage and cIMT was assessed in a multivariable quantile regression model where a p-value of
Databáze: OpenAIRE
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