The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis
| Autor: | Emine Dibek Misirlioglu, Can Naci Kocabaş, Dilek Azkur, Emine Vezir, Müge Toyran, Ayşegül Akan, Ersoy Civelek, Ayşenur Kaya, Mustafa Erkoçoğlu |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Eczema Dermatitis Contact Severity of Illness Index Dermatitis Atopic Allergic sensitization chemistry.chemical_compound Nickel Sleep Initiation and Maintenance Disorders Severity of illness medicine Humans SCORAD Sensitization medicine.diagnostic_test business.industry Pruritus Thimerosal Preservatives Pharmaceutical Patch test Infant Methylchloroisothiazolinone General Medicine Atopic dermatitis Allergens Patch Tests medicine.disease Dermatology Thiazoles medicine.anatomical_structure chemistry Child Preschool Female business Atopic dermatitis children contact allergen sensitization Contact dermatitis |
| Zdroj: | Volume: 45, Issue: 6 1207-1213 Turkish Journal of Medical Sciences |
| ISSN: | 1300-0144 1303-6165 |
| Popis: | Background/aim: Data about contact allergen sensitization (CAS) in children with atopic dermatitis (AD) are limited. The purpose of this study was to identify the frequency and patterns of CAS in children with AD by using a ready-to-use patch test system. Materials and methods: After receiving the history of CAS in the patients, the severity of AD and IgE-mediated allergen sensitization were determined. Results: Of 134 children with AD, 33.8% (n = 45) had at least 1 positive reaction. The most frequent positive reaction was to nickel sulfate (NS) (37.8%, 17/45), followed by methylchloroisothiazolinone (20.0%, 9/45) and thimerosal (15.6%, 7/45). The total Scoring Atopic Dermatitis (SCORAD) score was significantly higher in the NS-sensitized group (P = 0.036). The patients with NS sensitization had moderate-severe AD more frequently than those without any reaction (P = 0.020). When the SCORAD score was evaluated in detail, extent of eczema, score of sleep loss, and pruritus were significantly higher in the patients with NS sensitization than those without any reaction (P = 0.002, P = 0.001, and P = 0.002, respectively). Conclusion: Our study confirms the necessity of CAS in the management of AD. In particular, NS sensitization should be considered for children with severe AD or larger extent of eczema and trunk involvement. |
| Databáze: | OpenAIRE |
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