Mechanism of the Rhodium(III)-Catalyzed Arylation of Imines via C–H Bond Functionalization: Inhibition by Substrate
| Autor: | Jonathan A. Ellman, Robert G. Bergman, Michael E. Tauchert, Christopher D. Incarvito, Arnold L. Rheingold |
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| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular C h bond Substrate (chemistry) chemistry.chemical_element General Chemistry Photochemistry Hydrocarbons Aromatic Biochemistry Medicinal chemistry Article Catalysis Rhodium chemistry.chemical_compound Colloid and Surface Chemistry chemistry Functional group Surface modification Amine gas treating Imines Amines Stoichiometry |
| Zdroj: | Journal of the American Chemical Society. 134:1482-1485 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja211110h |
| Popis: | Rh(III)-catalyzed arylation of imines provides a new method for C-C bond formation while simultaneously introducing an α-branched amine as a functional group. This detailed mechanistic study provides insights for the rational future development of this new reaction. Relevant intermediate Rh(III) complexes have been isolated and characterized, and their reactivities in stoichiometric reactions with relevant substrates have been monitored. The reaction was found to be first order in the catalyst resting state and inverse first order in the C-H activation substrate. |
| Databáze: | OpenAIRE |
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