Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression
| Autor: | G Linares-Cruz, Fabien Calvo, Marcel Tuynder, M Medhioub, H der Sarkissan, Lydie Bougueleret, D. Le Paslier, Robert Amson, Adam Telerman, Mona Nemani, Heriberto Bruzzoni-Giovanelli, F Sigaux, Veronique Alvaro, Daniel Cohen, Jean-Pierre Roperch, Patricia Pasturaud, Ilya Chumakov, Dorra Cherif, Moshe Oren, Jean Dausset, Lucien Cazes, I Le Gall, David Israeli |
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| Přispěvatelé: | Service de Recherche en Hémato-Immunologie (SRHI - UMR_E 05), Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Oxford National Institute for Health Research Biomedical Research Centre/Molecular Diagnostic Centre, National Institute biomedical research centre, Serono Genetics Institute S.A.[Evry], Serono Genetics Institute, Department of Molecular Cell Biology [Rehovot], Weizmann Institute of Science [Rehovot, Israël], Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Department of Earth and Environmental Science [Socorro], New Mexico Institute of Mining and Technology [New Mexico Tech] (NMT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7) |
| Rok vydání: | 1996 |
| Předmět: |
Programmed cell death
DNA Complementary Ubiquitin-Protein Ligases [SDV]Life Sciences [q-bio] Molecular Sequence Data Apoptosis [SDV.CAN]Life Sciences [q-bio]/Cancer RNA-binding protein SIAH1 Biology 03 medical and health sciences 0302 clinical medicine Animals Humans Genes Tumor Suppressor [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Amino Acid Sequence Nuclear protein Gene In Situ Hybridization Fluorescence Gene Library 030304 developmental biology Regulation of gene expression Zinc finger [SDV.GEN]Life Sciences [q-bio]/Genetics 0303 health sciences Multidisciplinary Sequence Homology Amino Acid Nuclear Proteins Proteins Zinc Fingers Cell cycle Molecular biology Gene Expression Regulation 030220 oncology & carcinogenesis Chromosomes Human Pair 16 Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 1996, 93 (17), pp.9039-9042. ⟨10.1073/pnas.93.17.9039⟩ Proceedings of the National Academy of Sciences of the United States of America, 1996, 93 (17), pp.9039-9042. ⟨10.1073/pnas.93.17.9039⟩ |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.93.17.9039 |
| Popis: | International audience; Developmentally regulated genes in Drosophila, which are conserved through evolution, are potential candidates for key functions in biological processes such as cell cycle, programmed cell death, and cancer. We report cloning and characterization of the human homologue of the Drosophila seven in absentia gene (HUMSIAH), which codes for a 282 amino acids putative zinc finger protein. HUMSIAH is localized on human chromosome 16q12-q13. This gene is activated during the physiological program of cell death in the intestinal epithelium. Moreover, human cancer-derived cells selected for suppression of their tumorigenic phenotype exhibit constitutively elevated levels of HUMSIAH mRNA. A similar pattern of expression is also displayed by the p21waf1. These results suggest that mammalian seven in absentia gene, which is a target for activation by p53, may play a role in apoptosis and tumor suppression. |
| Databáze: | OpenAIRE |
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