Predicting Alzheimer disease from a blood-based biomarker profile
| Autor: | Noel G. Faux, Samantha C. Burnham, James D. Doecke, Ashley I. Bush, Greg Savage, David Baker, Paul Maruff, Colin L. Masters, Stephanie R. Rainey-Smith, Ralph N. Martins, S. Lance Macaulay, David Ames, Simon M. Laws, Victor L. Villemagne, Christopher C. Rowe, William Wilson |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Apolipoprotein E Oncology medicine.medical_specialty Standardized uptake value Neuropsychological Tests Bioinformatics 03 medical and health sciences Cognition 0302 clinical medicine Alzheimer Disease Internal medicine Odds Ratio medicine Humans Cognitive Dysfunction Cognitive decline Prospective cohort study Aged Aged 80 and over Analysis of Variance Amyloid beta-Peptides business.industry Brain Odds ratio medicine.disease 030104 developmental biology Positron-Emission Tomography Disease Progression Linear Models Biomarker (medicine) Female Neurology (clinical) Analysis of variance Alzheimer's disease business Biomarkers Blood Chemical Analysis 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Neurology. 87:1093-1101 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | Objective:We assessed a blood-based signature, which previously demonstrated high accuracy at stratifying individuals with high or low neocortical β-amyloid burden (NAB), to determine whether it could also identify individuals at risk of progression to Alzheimer disease (AD) within 54 months.Methods:We generated the blood-based signature for 585 healthy controls (HCs) and 74 participants with mild cognitive impairment (MCI) from the Australian Imaging, Biomarkers and Lifestyle Study who underwent clinical reclassification (blinded to biomarker findings) at 54-month follow-up. The individuals were split into estimated high and low NAB groups based on a cutoff of 1.5 standardized uptake value ratio. We assessed the predictive accuracy of the high and low NAB groupings based on progression to mild cognitive impairment or AD according to clinical reclassification at 54-month follow-up.Results:Twelve percent of HCs with estimated high NAB progressed in comparison to 5% of HCs with estimated low NAB (odds ratio = 2.4). Forty percent of the participants with MCI who had estimated high NAB progressed in comparison to 5% of the participants with MCI who had estimated low NAB (odds ratio = 12.3). These ratios are in line with those reported for Pittsburgh compound B–PET results. Individuals with estimated high NAB had faster rates of memory decline than those with estimated low NAB.Conclusion:These findings suggest that a simple blood-based signature not only provides estimates of NAB but also predicts cognitive decline and disease progression, identifying individuals at risk of progressing toward AD at the prodromal and preclinical stages. |
| Databáze: | OpenAIRE |
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