Histone Acetyltransferases in Cancer: Guardians or Hazards?
| Autor: | Christina Demetriadou, Antonis Kirmizis |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Histone Acetyltransferases Cancer Research biology Carcinogenesis Cancer Acetylation Context (language use) medicine.disease medicine.disease_cause Chromatin Histones 03 medical and health sciences 030104 developmental biology Histone Neoplasms biology.protein medicine Cancer research Animals Humans Epigenetics |
| Zdroj: | Critical Reviews™ in Oncogenesis. 22:195-218 |
| ISSN: | 0893-9675 |
| DOI: | 10.1615/critrevoncog.2017024506 |
| Popis: | Histone acetyltransferases (HATs) catalyzing N-epsilon-lysine or N-alpha-terminal acetylation on histone and non-histone substrates are important epigenetic regulators controlling gene expression and chromatin structure. Deregulation of these enzymes by genetic or epigenetic alterations accompanied by defects in gene transcription have been implicated in oncogenesis. Therefore, these enzymes are considered promising therapeutic targets, offering new horizons for epigenetic cancer therapy. However, recent observations suggest that these enzymes function as both oncogenes and tumor suppressors. In this review, we present the current evidence demonstrating that individual HATs can either prevent cancer cell proliferation or drive malignant transformation depending on the molecular context and cancer type. We therefore advocate that future therapeutic interventions targeted toward these enzymes should carefully consider the fact that HATs commonly have a two-sided role in carcinogenesis. |
| Databáze: | OpenAIRE |
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