Successful Treatment of Systemic Exophiala dermatitidis Infection in a Patient with Chronic Granulomatous Disease
| Autor: | John I. Gallin, Richard T. Kenney, Maria J. Merino, Harvey I. Pass, A T Waytes, D A Melnick, Kyung J. Kwon-Chung |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Microbiology (medical) Pathology medicine.medical_specialty Brain Abscess Granulomatous Disease Chronic Flucytosine Chronic granulomatous disease Exophiala Amphotericin B medicine Humans Lung Lung Diseases Fungal biology business.industry biology.organism_classification medicine.disease Combined Modality Therapy Magnetic Resonance Imaging Radiography Leukocyte Transfusion Infectious Diseases medicine.anatomical_structure Mycoses Immunology Microscopy Electron Scanning Female Ketoconazole business Fluconazole Exophiala dermatitidis medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 14:235-242 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/clinids/14.1.235 |
| Popis: | Exophiala dermatitidis, one of the saprophytic dematiaceous fungi, is a rare cause of human infection that, when invasive, is nearly always fatal. Besides the more common subcutaneous infection usually caused by traumatic inoculation, infection can also spread hematogenously, in which case the organism has a distinct neurotropism. A patient with autosomal recessive chronic granulomatous disease of childhood who was found to have a progressive pulmonary and central nervous system infection with E. dermatitidis responded to an aggressive, multifaceted therapeutic approach. Scanning electron microscopy of the cultured conidiogenous cells confirmed that the manner of conidiogenesis is typical of the genus Exophiala. We report the first successful treatment of an infection involving the lungs and central nervous system by a combination of surgical resection of the pulmonary source and medical therapy with amphotericin B, flucytosine or ketoconazole, and transfused white cells, followed by a prolonged course of fluconazole. |
| Databáze: | OpenAIRE |
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