Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells
| Autor: | Andrée-Anne Grosset, Louis Gaboury, Yves St-Pierre, Melanie Demers, Peter M. Siegel, April A.N. Rose, Katherine Biron-Pain |
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| Přispěvatelé: | Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), Goodman Cancer Research Center [Montréal] (GCRC), McGill University = Université McGill [Montréal, Canada], Institut de Recherche en Immunologie et en Cancérologie [UdeM-Montréal] (IRIC), Université de Montréal (UdeM) |
| Rok vydání: | 2010 |
| Předmět: |
CA15-3
Pathology Lung Neoplasms MESH: Mammary Glands Human Metastasis Mice [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Tumor Cells Cultured MESH: Animals Neoplasm Metastasis Mice Inbred BALB C MESH: Middle Aged MESH: Mammary Glands Animal Middle Aged MESH: Bone Neoplasms Metastatic breast cancer MESH: Epithelial Cells MESH: Galectins Female Breast disease Breast carcinoma Adult medicine.medical_specialty Galectins MESH: Mice Inbred BALB C Bone Neoplasms Breast Neoplasms Biology Pathology and Forensic Medicine Breast cancer Mammary Glands Animal medicine otorhinolaryngologic diseases Animals Humans MESH: Tumor Cells Cultured Mammary Glands Human MESH: Mice MESH: Humans MESH: Biological Markers Myoepithelial cell Cancer MESH: Adult Epithelial Cells medicine.disease MESH: Neoplasm Metastasis MESH: Lung Neoplasms stomatognathic diseases MESH: Female MESH: Breast Neoplasms Biomarkers Regular Articles |
| Zdroj: | American Journal of Pathology American Journal of Pathology, American Society for Investigative Pathology, 2010, 176 (6), pp.3023-31. ⟨10.2353/ajpath.2010.090876⟩ |
| ISSN: | 1525-2191 0002-9440 |
| DOI: | 10.2353/ajpath.2010.090876⟩ |
| Popis: | International audience; Galectins are members of a family of beta-galactosides-binding proteins that have recently emerged as novel modulators in different aspects of cancer. The expression of galectins in tumors and/or the tissue surrounding them has been well documented. Since galectin-7 expression has been associated with epithelial tissues and varies significantly in various types of cancer, we have investigated for the first time its role in breast cancer. Using two preclinical mouse models, high levels of galectin-7 expression in breast cancer cells drastically increased their ability to metastasize to lungs and bones. Significant increases in the number of pulmonary metastases and osteolytic lesions were induced by overexpression of galectin-7 compared with control cells. In human tissues, galectin-7 was specifically found in myoepithelial cells of normal human breast tissue, but not in luminal cells. Its expression was severely altered in breast carcinoma, many samples showing greater than 70% of galectin-7 positive cells. High expression levels of galectin-7 were restricted to high-grade breast carcinomas, including HER2 overexpressing and basal-like groups. In HER2 overexpressing cases, galectin-7 expression was associated with lymph node axillary metastasis. Taken together, our results indicate that galectin-7 may represent a potential target for both specific detection and therapeutic inhibition of metastatic breast cancer. |
| Databáze: | OpenAIRE |
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