High-Fat Diet and Female Fertility
| Autor: | Natalie M. Hohos, Malgorzata E. Skaznik-Wikiel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Infertility medicine.medical_specialty media_common.quotation_subject Adipose tissue Fertility Diet High-Fat 03 medical and health sciences Endocrinology Internal medicine medicine Humans Obesity media_common Reproductive function biology business.industry Leptin Mini-Review medicine.disease Insulin receptor 030104 developmental biology Lipotoxicity biology.protein Female business Infertility Female |
| Popis: | The prevalence of obesity is high among reproductive-age women and is associated with impaired reproductive function. Obesity is multifactorial in origin, yet many cases of obesity result from overconsumption of a diet high in fat. Excess dietary fat increases both adipose and nonadipose tissue lipid content and, through lipotoxicity, leads to cell dysfunction and death. High dietary fat intake, with or without the development of obesity, impairs female hypothalamic-pituitary-ovarian (HPO) axis functionality and fertility. Based on the current evidence, it appears the reproductive dysfunction involves increased leptin and insulin signaling at the various levels of the HPO axis, as well as changes in peroxisome proliferator-activated receptor γ actions and increased inflammation, yet other mechanisms may also be involved. This review summarizes the current body of knowledge on impaired female reproductive function after high-fat diet exposure, as well as discusses proposed mechanisms through which this may occur. |
| Databáze: | OpenAIRE |
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