Cholesterol and Egg Intakes with Cardiometabolic and All-Cause Mortality among Chinese and Low-Income Black and White Americans
| Autor: | William J. Blot, Xiong-Fei Pan, Wei Zheng, Loren Lipworth, Mark Steinwandel, Hui Cai, Danxia Yu, Jae-Jeong Yang, Xiao-Ou Shu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Inverse Association China Eggs 030204 cardiovascular system & hematology Article White People Cholesterol Dietary 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Asian People Medicine Humans TX341-641 030212 general & internal medicine Prospective Studies Prospective cohort study Poverty Aged Metabolic Syndrome prospective cohort study Nutrition and Dietetics cardiometabolic disease Nutrition. Foods and food supply business.industry Cholesterol Proportional hazards model Confounding Hazard ratio Middle Aged Egg intake mortality Confidence interval United States Diet Black or African American chemistry Women's Health dietary cholesterol Female business Men's Health Food Science Demography egg intake |
| Zdroj: | Nutrients Volume 13 Issue 6 Nutrients, Vol 13, Iss 2094, p 2094 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13062094 |
| Popis: | We examined the associations of dietary cholesterol and egg intakes with cardiometabolic and all-cause mortality among Chinese and low-income Black and White Americans. Included were 47,789 Blacks, 20,360 Whites, and 134,280 Chinese aged 40–79 years at enrollment. Multivariable Cox models with restricted cubic splines were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality outcomes using intakes of 150 mg cholesterol/day and 1 egg/week as the references. Cholesterol intake showed a nonlinear association with increased all-cause mortality and a linear association with increased cardiometabolic mortality among Black Americans: HRs (95% CIs) associated with 300 and 600 mg/day vs. 150 mg/day were 1.07 (1.03–1.11) and 1.13 (1.05–1.21) for all-cause mortality (P-linearity = 0.04, P-nonlinearity = 0.002, and P-overall < 0.001) and 1.10 (1.03–1.16) and 1.21 (1.08–1.36) for cardiometabolic mortality (P-linearity = 0.007, P-nonlinearity = 0.07, and P-overall = 0.005). Null associations with all-cause or cardiometabolic mortality were noted for White Americans (P-linearity ≥ 0.13, P-nonlinearity ≥ 0.06, and P-overall ≥ 0.05 for both). Nonlinear inverse associations were observed among Chinese: HR (95% CI) for 300 vs. 150 mg/day was 0.94 (0.92–0.97) for all-cause mortality and 0.91 (0.87–0.95) for cardiometabolic mortality, but the inverse associations disappeared with cholesterol intake > 500 mg/day (P-linearity ≥ 0.12 P-nonlinearity ≤ 0.001 P-overall < 0.001 for both). Similarly, we observed a positive association of egg intake with all-cause mortality in Black Americans, but a null association in White Americans and a nonlinear inverse association in Chinese. In conclusion, the associations of cholesterol and egg intakes with cardiometabolic and all-cause mortality may differ across ethnicities who have different dietary patterns and cardiometabolic risk profiles. However, residual confounding remains possible. |
| Databáze: | OpenAIRE |
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