Synthesis of a Novel C-Nucleoside, 2-Amino-7-(2-deoxy-β- D-erythro-pentofuranosyl)-3H,5H-pyrrolo-[3,2-d]pyrimidin-4-one (2′-Deoxy-9-deazaguanosine)
| Autor: | Krzysztof W. Pankiewicz, Krystyna Lesiak, Eric S. Gibson, Kyoichi A. Watanabe, Lorraine J. Gudas |
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| Rok vydání: | 1999 |
| Předmět: |
Antimetabolites
Antineoplastic Magnetic Resonance Spectroscopy Anomer Cell Survival Stereochemistry Molecular Conformation Lymphoma T-Cell Biochemistry Mice chemistry.chemical_compound Tumor Cells Cultured Genetics Animals Deoxyguanosine C nucleosides Leukemia L1210 Cell survival Molecular Structure Diastereomer Nuclear magnetic resonance spectroscopy chemistry Proton NMR Indicators and Reagents Drug Screening Assays Antitumor |
| Zdroj: | Nucleosides and Nucleotides. 18:363-376 |
| ISSN: | 0732-8311 |
| DOI: | 10.1080/15257779908043082 |
| Popis: | A synthesis of the C-nucleoside, 2-amino-7-(2-deoxy-beta-D-erythro- pentofuranosyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one (9-deaza-2'-deoxyguanosine) was achieved starting from 2-amino-6-methyl-3H-pyrimidin-4-one (5) and methyl 2-deoxy-3,5-di-O-(p-nitrobenzoyl)-D-erythro-pento-furanoside (11). The anomeric configuration of the C-nucleoside was established by 1H NMR, NOEDS and ROESY. This C-nucleoside did not inhibit the growth of T-cell lymphoma cells. |
| Databáze: | OpenAIRE |
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