Hepatitis C virus entry: potential receptors and their biological functions
| Autor: | Cécile Voisset, Laurence Cocquerel, Jean Dubuisson |
|---|---|
| Přispěvatelé: | Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Droit et Santé, Our research was supported by the ‘Agence Nationale de Recherche sur le Sida et les hépatites virales' (ANRS), INSERM ‘ATC-Hépatite C’ and the ‘Association pour la Recherche sur le Cancer’ (ARC). C. V. was supported by a post-doctoral fellowship from the ANRS and J. D. is an international scholar of the Howard Hughes Medical Institute (HHMI)., We thank Sophana Ung for preparing the illustrations. |
| Rok vydání: | 2006 |
| Předmět: |
CD36 Antigens
Hepatitis C virus MESH: Receptors Virus/physiology Hepacivirus Biology Virus Replication medicine.disease_cause Virus MESH: CD36 Antigens/metabolism Tetraspanin 28 MESH: Tetraspanin 28 03 medical and health sciences Viral Envelope Proteins Tetraspanin Antigens CD MESH: Receptors Virus/metabolism Virology MESH: Glycosaminoglycans/metabolism medicine Humans MESH: CD36 Antigens/physiology Lectins C-Type Scavenger receptor Receptor MESH: Antigens CD/physiology Glycosaminoglycans 030304 developmental biology 0303 health sciences MESH: Humans MESH: Antigens CD/metabolism MESH: Virus Replication 030302 biochemistry & molecular biology virus diseases MESH: Viral Envelope Proteins/metabolism MESH: Receptors LDL/metabolism digestive system diseases 3. Good health NS2-3 protease MESH: Hepacivirus/physiology Receptors LDL MESH: Hepatocytes/virology [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Hepatocytes Receptors Virus Asialoglycoprotein receptor MESH: Lectins C-Type/metabolism CD81 |
| Zdroj: | Journal of General Virology Journal of General Virology, Microbiology Society, 2006, 87 (5), pp.1075-1085. ⟨10.1099/vir.0.81646-0⟩ |
| ISSN: | 1465-2099 0022-1317 |
| DOI: | 10.1099/vir.0.81646-0 |
| Popis: | Several cellular molecules have been identified as putative receptors forHepatitis C virus(HCV): CD81 tetraspanin, scavenger receptor class B type I (SR-BI), mannose-binding lectins DC-SIGN and L-SIGN, low-density lipoprotein receptor, heparan sulphate proteoglycans and the asialoglycoprotein receptor. Due to difficulties in propagating HCV in cell culture, most of these molecules have been identified by analysing their interaction with a soluble, truncated form of HCV glycoprotein E2. A recent major step in investigating HCV entry was the development of pseudoparticles (HCVpp), consisting of unmodified HCV envelope glycoproteins assembled onto retroviral core particles. This system has allowed the investigation of the role of candidate receptors in the early steps of the HCV life cycle and the data obtained can now be confirmed with the help of a newly developed cell-culture system that allows efficient amplification of HCV (HCVcc). Interestingly, CD81 and SR-BI have been shown to play direct roles in HCVpp and/or HCVcc entry. However, co-expression of CD81 and SR-BI in non-hepatic cell lines does not lead to HCVpp entry, indicating that other molecule(s), expressed only in hepatic cells, are necessary for HCV entry. In this review, the molecules that have been proposed as potential HCV receptors are described and the experimental data indicating that CD81 and SR-BI are potentially involved in HCV entry are presented. |
| Databáze: | OpenAIRE |
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