Study of MRI brain findings and carotid US features in systemic sclerosis patients, relationship with disease parameters

Autor: Mohamed Aboel-Kassem F. Abdelmegid, Hanan Sayed M. Abozaid, Lobna Abdel-Wahid Mohram, Sahar Abd Elrahman Alsayed, Nashwa Mostafa A. Azoz, Rania M. Gamal, Amr F. Mourad, Mohmed Raouf Abdel-Razek, Mohmed Zidan, Daniel E. Furst
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Adult
Carotid Artery Diseases
Male
medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system
Intima-media thickness
Central nervous system
Disease
Fluid-attenuated inversion recovery
Carotid Intima-Media Thickness
Lesion
03 medical and health sciences
0302 clinical medicine
medicine.artery
Internal medicine
medicine
Humans
Common carotid artery
cardiovascular diseases
skin and connective tissue diseases
030203 arthritis & rheumatology
Autoimmune disease
Scleroderma
Systemic
business.industry
Brain
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Rheumatology
030104 developmental biology
medicine.anatomical_structure
Carotid Arteries
Cross-Sectional Studies
Brain MRI
Cardiology
cardiovascular system
Systemic sclerosis
Female
medicine.symptom
lcsh:RC925-935
business
Research Article
Zdroj: Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-8 (2019)
ISSN: 1478-6362
1478-6354
Popis: Background/objectives Systemic sclerosis (SSc) is an autoimmune disease associated with immune abnormalities and widespread vascular lesions, including increased intimal and medial thickness. These changes may be reflected in early atherosclerosis and cardiovascular risks. We aimed in this study to examine the carotid artery intima-media thickness and MRI brain findings in SSc patients and compared them to a group of normal controls. A relationship between these parameters and clinical measures in SSc was also sought. Methods Seventy-two SSc patients with no central nervous system (CNS) symptoms and 42 healthy controls were included. Clinical and laboratory measures, Medsger’s severity scale, and Doppler ultrasound common carotid artery intima-media thickness (CCA-IMT) were measured. Brain fluid-attenuated inversion recovery (FLAIR)-MRI and diffusion-weighted MRI (DWI) were also done. Results SSc patients had more CCA-IMT, higher CRP, and more brain MRI hyperintense lesions than controls (P
Databáze: OpenAIRE
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