Random peptide mixtures entrapped within a copper-cuprite matrix: new antimicrobial agent against methicillin-resistant Staphylococcus aureus
Autor: | Zvi Hayouka, Barak Menagen, Tal Stern Bauer, David Avnir |
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Rok vydání: | 2019 |
Předmět: |
Methicillin-Resistant Staphylococcus aureus
0301 basic medicine lcsh:Medicine chemistry.chemical_element Drug resistance medicine.disease_cause Article Microbiology 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Anti-Infective Agents medicine lcsh:Science Multidisciplinary Chemistry lcsh:R Biomaterial Drug Resistance Microbial Pathogenic bacteria Antimicrobial Chemical biology Methicillin-resistant Staphylococcus aureus Copper 030104 developmental biology Staphylococcus aureus lcsh:Q Bacterial infection Peptides 030217 neurology & neurosurgery |
Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | The emergence of global antibiotic resistance necessitates the urgent need to develop new and effective antimicrobial agents. Combination of two antimicrobial agents can potentially improve antimicrobial potency and mitigate the development of resistance. Therefore, we have utilized metal molecular doping methodology whereby antimicrobial random peptides mixture (RPMs) are entrapped in a bactericidal copper metal matrix. The copper/RPM composite exhibits greater antimicrobial activity toward methicillin-resistant Staphylococcus aureus (MRSA) than either copper or RPMs alone. Our findings indicate that this bactericidal antimicrobial biomaterial could be utilized to efficiently eradicate antibiotic-resistant pathogenic bacteria for health, agricultural and environmental applications. |
Databáze: | OpenAIRE |
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