Fabrication of collagen scaffolds impregnated with sago starch capped silver nanoparticles suitable for biomedical applications and their physicochemical studies
| Autor: | Abhishek Mandal, Amitava Mukherjee, Thotapalli Parvathaleswara Sastry, Asit Baran Mandal, Santhanam Sekar, Kamal Mohamed Seeni Meera |
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| Rok vydání: | 2014 |
| Předmět: |
Staphylococcus aureus
Silver Fabrication Cell Survival Starch Metal Nanoparticles General Physics and Astronomy Biocompatible Materials Microbial Sensitivity Tests Silver nanoparticle Mice chemistry.chemical_compound Tensile Strength Spectroscopy Fourier Transform Infrared Ultimate tensile strength Escherichia coli Sago starch Animals Thermal stability Physical and Theoretical Chemistry Calorimetry Differential Scanning Chemistry Biocompatible material Anti-Bacterial Agents Thermogravimetry Chemical engineering NIH 3T3 Cells Collagen Porosity |
| Zdroj: | Phys. Chem. Chem. Phys.. 16:20175-20183 |
| ISSN: | 1463-9084 1463-9076 |
| DOI: | 10.1039/c4cp02554g |
| Popis: | The present investigation attempts at fabricating collagen-based scaffolds impregnated with sago starch capped silver nanoparticles (AgNPs), useful for biomedical applications, and aims at studying their physicochemical aspects. AgNPs synthesized through a chemical reduction method, capped using different concentrations of sago starch, are incorporated into collagen derived from fish scales, and lyophilized to form scaffolds. FT-IR spectra confirm and validate the interaction of sago starch capped AgNPs with collagen in the scaffolds. TGA and DSC results indicate enhanced thermal stability of collagen scaffolds impregnated with sago capped AgNPs compared to collagen alone. All the collagen scaffolds containing sago starch capped AgNPs show high tensile strength values for their use as wound dressing materials. Moreover, lower minimum inhibitory concentration values are obtained for the above capped AgNP collagen scaffolds, which indicate higher antibacterial activities compared to uncapped AgNPs tested against both gram positive and negative bacterial strains. The novelty is that the developed scaffolds are biodegradable and in vitro studies reveal them as biocompatible and suitable for tissue regeneration applications. |
| Databáze: | OpenAIRE |
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