Aberrant cortical neurodevelopment in major depressive disorder
| Autor: | Malte S. Depping, Claudia Bach, Nadine D. Wolf, Dusan Hirjak, Robert Christian Wolf, Mike M. Schmitgen, Nenad Vasic, Fabio Sambataro, Katharina M. Kubera |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Vulnerability Prefrontal Cortex Cortical thickness 03 medical and health sciences 0302 clinical medicine Neuroimaging Parietal Lobe medicine Humans Child Cortex Depression Gyrification MRI Prefrontal cortex Cerebral Cortex Depressive Disorder Major Depressive Disorder medicine.diagnostic_test business.industry Parietal lobe Major Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies medicine.anatomical_structure Cerebral cortex Case-Control Studies Disease Progression Major depressive disorder Female Occipital Lobe Occipital lobe business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Affective Disorders. 243:340-347 |
| ISSN: | 0165-0327 |
| Popis: | There is strong neuroimaging evidence that cortical alterations represent a core pathophysiological feature of major depressive disorder (MDD). Differential contributions of cortical features of neurodevelopmental origin, which may distinctly contribute to MDD vulnerability, disease-onset, or symptom expression, are unclear at present.We investigated distinct markers of cortical neurodevelopment, i.e. local cortical gyrification (LGI) and thickness (CT) in patients with MDD (n = 38) and healthy controls (HC, n = 22) using 3 T structural magnetic resonance imaging data and surface-based data analysis techniques. CT and LGI were computed using the Computational Anatomy Toolbox (CAT12). Analyses were performed for the entire cortical surface followed by a complementary regions-of-interest approach.MDD patients showed significantly greater LGI in frontal, cingulate, parietal, temporal, and occipital regions compared to HC (FDR-corrected at p 0.05 using threshold-free cluster enhancement). No significant differences of CT were found. In the MDD-group, correlations were found between duration of illness in years and number of depressive episodes and LGI of frontal, temporal, and parietal regions (p 0.05).Main limitations are the relatively modest sample size and a cross-sectional study design. We did not control for early environmental factors potentially influencing neurodevelopment, such as childhood trauma. We report associations uncorrected for multiple comparisons.The data suggest different local trajectories of cortical change in MDD. In addition, our data support the notion that aberrant cortical development may serve as a vulnerability marker of MDD, as well as a potential predictor of disease course. |
| Databáze: | OpenAIRE |
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