Gene Variants in Hepatic Metabolism, Gamma-Aminobutyric Acid-ergic Reward, and Prostaglandin Pathways in Opioid-Consuming and Opioid-Naïve Patients Presenting for Lower Extremity Total Joint Replacement
| Autor: | Kathleen C. Light, Ami R. Stuart, Daniel W. Odell, Alan R. Light, Ken B. Johnson |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pain Threshold Adolescent Pharmacogenomic Variants Prostaglandin Inflammation Bioinformatics Polymorphism Single Nucleotide gamma-Aminobutyric acid Young Adult chemistry.chemical_compound Reward medicine Genetic predisposition Humans Arthroplasty Replacement Gene gamma-Aminobutyric Acid Aged Pain Postoperative Biological Variation Individual business.industry Pain Perception Middle Aged Analgesics Opioid Treatment Outcome Anesthesiology and Pain Medicine Liver Opioid chemistry Prostaglandins Female Opiate medicine.symptom Transcriptome business Drug metabolism medicine.drug |
| Zdroj: | Anesthesia & Analgesia. 130:e67-e70 |
| ISSN: | 0003-2999 |
| Popis: | Gene variants may contribute to individual differences in the experience of pain and the efficacy and reward of treatments. We explored gene variation in opioid-naïve and opioid-consuming patients undergoing elective lower extremity total joint replacement. We focused on 3 gene pathways including prostaglandin, gamma-aminobutyric acid (GABA)-ergic reward, and hepatic metabolism pathways. We report that for genes with possible or probable deleterious impact in these 3 pathways, opioid consumers had more gene variants than opioid-naïve patients (median 3 vs 1, P = .0092). We conclude that chronic opiate users may have genetic susceptibility to altered responses in reward/dependency and pain/inflammation pathways. |
| Databáze: | OpenAIRE |
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