Diagnosis and origin determination of malignant pleural effusions through the use of the breast cancer marker human mammaglobin
| Autor: | Anna Maria Carletti, Silvio Roncella, Bartolomeo Bacigalupo, Massimiliano Sivori, Franco Fedeli, Paolo Dessanti, Paola Ferro, Pier Aldo Canessa, Maria Pia Pistillo, Vincenzo Fontana, Maria Cristiana Franceschini |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Breast Neoplasms Malignancy Pathology and Forensic Medicine Young Adult Mammaglobin Breast cancer Internal medicine medicine Chi-square test Biomarkers Tumor Malignant pleural effusion Humans Uteroglobin Mesothelioma Lung cancer Molecular Biology Aged Aged 80 and over biology business.industry Reverse Transcriptase Polymerase Chain Reaction Mammaglobin A Cell Biology Middle Aged medicine.disease United States Neoplasm Proteins Pleural Effusion Malignant biology.protein Diagnostic odds ratio Female business |
| Zdroj: | Diagnostic molecular pathology : the American journal of surgical pathology, part B. 19(2) |
| ISSN: | 1533-4066 |
| Popis: | As was reported that human mammaglobin (hMAM) may be expressed in malignant pleural effusions (PEs), we investigated the relevance of hMAM reverse-transcriptase polymerase chain reaction (RT-PCR) for their diagnosis and determination of primary origin. Two hundred and twenty-eight malignant (132 male, 96 female) and 185 benign (132 male, 53 female) PEs were investigated. Statistical analyses evaluated the diagnostic performance parameters in all PEs and in cytologically negative malignant PEs, the association between hMAM and benign or malignant status by the direct index of correlation [diagnostic odds ratio (DOR)], chi test, and P value (P). In addition, the discriminative diagnostic power of hMAM expression, independently in breast cancer, lung cancer (LC), malignant mesothelioma (MM), and other cancers was evaluated. In the entire patient population, hMAM was detected in 45.6% and 5.4% of malignant and benign PEs, respectively, in the male group in 41.7% and 4.5% and in the female group in 51.0% and 7.5% of malignant and benign PEs, respectively. A statistically significant correlation between hMAM and malignancy was found in the entire population (DOR=14.68, P |
| Databáze: | OpenAIRE |
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