Imaging findings in epithelioid hemangioendothelioma
Autor: | Cameron C. Trenor, Frederic Thomas-Chausse, Ahmad I. Alomari, Yan Epelboym, Alyaa Al-Ibraheemi, Dawn R. Engelkemier, Denise M. Adams, Gulraiz Chaudry |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male Pathology medicine.medical_specialty Axial skeleton Adolescent Biopsy Bone Neoplasms Soft Tissue Neoplasms Malignancy 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences Young Adult 0302 clinical medicine Medicine Humans Radiology Nuclear Medicine and imaging Child Epithelioid hemangioendothelioma Aged Retrospective Studies Lung medicine.diagnostic_test business.industry Liver Neoplasms Soft tissue Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure 030220 oncology & carcinogenesis Child Preschool Hemangioendothelioma Epithelioid Female Lymph medicine.symptom business |
Zdroj: | Clinical imaging. 58 |
ISSN: | 1873-4499 |
Popis: | Purpose-objective Epithelioid hemangioendothelioma (EHE) is a rare vascular malignancy with varying biologic behavior. The purpose of this study was to identify imaging findings most characteristic of EHE. Methods Retrospective review of clinical and imaging records in patients referred to our Vascular Anomalies Center over a 17 year period with biopsy proven EHE. Results We evaluated 29 patients (17 F) with median age of 16 years (range 2–76 y). The most common presenting symptoms were pain (n = 13) and palpable mass (n = 7). 22 (70%) had multifocal disease. Most common sites of involvement were lung (n = 25), liver (n = 16), bone (n = 12), soft tissue (n = 3) and lymph nodes (n = 1). Of patients with single site disease, 3 had lung, 3 liver, and 1 had bone lesions. In 18/25 with lung disease, there were multiple nodules of varying sizes and characteristics. In 14/16 with hepatic disease there were multiple nodules with predominantly peripheral distribution. Subcapsular retraction was seen in 10/16 and a “lollipop” sign (hepatic or portal vein tapering at the edge of a well-defined hypoenhancing lesion) identified in 5/16. Of 12 osseous lesions, 11 were lytic, 8 involved vertebrae and 9 involved the axial skeleton. Conclusion EHE has varied imaging findings. The most common sites are lungs, liver, and bone, with multi-organ involvement seen in most. Lung disease is most commonly characterized by multiple nodules. Hepatic lesions demonstrate the most distinctive findings, with peripheral distribution, lack of early enhancement, subcapsular retraction and “lollipop” sign. Osseous lesions are commonly lytic and more prevalent in the axial skeleton. |
Databáze: | OpenAIRE |
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