A Polymer-Based Extended Release System for Stable, Long-term Intracochlear Drug Delivery
| Autor: | Thomas J. Smith, Erik Pierstorff, Marc M. Baum, William H. Slattery, Su Young Ryu, Maria Paola Chaparro, Yen-Jung Angel Chen, Shanshan Chen, Stacey Ludwig, Wan Wan Yang, Federico Kalinec, Sherry M Tsai, John M. Cortez |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
Polymers medicine.drug_class media_common.quotation_subject Guinea Pigs Clinical Sciences Anti-Inflammatory Agents Perilymph Pilot Projects Article Fluticasone propionate Inner ear disorders 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Hearing In vivo otorhinolaryngologic diseases medicine Animals Corticosteroids Polymer 030223 otorhinolaryngology Fluticasone media_common Round window business.industry Guinea pig Sensory Systems Cochlea medicine.anatomical_structure Otorhinolaryngology Delayed-Action Preparations Anesthesia Drug delivery Public Health and Health Services Corticosteroid Neurology (clinical) business Zoology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, vol 39, iss 9 Pierstorff, E; Chen, S; Chaparro, MP; Cortez, JM; Chen, Y-J; Ryu, SY; et al.(2018). A Polymer-Based Extended Release System for Stable, Long-term Intracochlear Drug Delivery.. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 39(9), 1195-1202. doi: 10.1097/mao.0000000000001977. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1gm9z167 |
| ISSN: | 1537-4505 1531-7129 |
| DOI: | 10.1097/mao.0000000000001977 |
| Popis: | Author(s): Pierstorff, Erik; Chen, Shanshan; Chaparro, Maria Paola; Cortez, John M; Chen, Yen-Jung; Ryu, Su Young; Tsai, Sherry M; Baum, Marc M; Yang, Wan Wan; Kalinec, Federico; Smith, Thomas; Ludwig, Stacey; Slattery, William H | Abstract: ObjectiveInvestigate a new polymer-based drug coating suitability for safe intracochlear delivery and ability to maintain long-term physiologically active levels of the corticosteroid fluticasone propionate.Study designIn vitro dissolution study to evaluate release profiles of polymer-coated drug particles and in vivo studies using a guinea pig model to measure perilymph drug concentrations at specific time points after implantation with polymer-coated drug particles and evaluate their effect on hearing function.MethodsPolymer-coated fluticasone propionate (FP) particles were surgically implanted in guinea pigs through the round window membrane into the cochlear scala tympani. In the pilot study, pre- and post-op hearing thresholds were conducted on days 7, 14, and 42. In a second study, post-op hearing thresholds were conducted on days 90, 120, and 180. Perilymph drug concentrations were measured on the same time points.ResultsIn 15 of 16 animals from day 7 through day 90, drug levels were within the targeted range, with no initial burst release detected. Drug was present in all animals on day 90 and was detected in some animals at 120 and 180 days. Hearing was tested and compared with non-implanted ears. Very good hearing preservation was observed in ears implanted with intracochlear particles when compared with contralateral ears.ConclusionsThe polymer-based extended release system is effective in providing long-term, stable drug delivery for at least 90 days with good hearing outcomes. The results of this study support the potential for achieving long-term drug delivery with a single intracochlear administration. |
| Databáze: | OpenAIRE |
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