Neural ensemble reactivation in rapid eye movement and slow-wave sleep coordinate with muscle activity to promote rapid motor skill learning
| Autor: | Bruce L. McNaughton, Masami Tatsuno, M J Eckert |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
education Rapid eye movement sleep Hippocampus Sleep REM Sleep Slow-Wave General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine mental disorders medicine Animals Learning Motor skill 030304 developmental biology Slow-wave sleep Memory Consolidation 0303 health sciences musculoskeletal neural and ocular physiology Eye movement Articles Sleep in non-human animals Rats medicine.anatomical_structure Motor Skills Memory consolidation General Agricultural and Biological Sciences Psychology Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes Motor cortex |
| Zdroj: | Philos Trans R Soc Lond B Biol Sci |
| Popis: | Neural activity patterns of recent experiences are reactivated during sleep in structures critical for memory storage, including hippocampus and neocortex. This reactivation process is thought to aid memory consolidation. Although synaptic rearrangement dynamics following learning involve an interplay between slow-wave sleep (SWS) and rapid eye movement (REM) sleep, most physiological evidence implicates SWS directly following experience as a preferred window for reactivation. Here, we show that reactivation occurs in both REM and SWS and that coordination of REM and SWS activation on the same day is associated with rapid learning of a motor skill. We performed 6 h recordings from cells in rats' motor cortex as they were trained daily on a skilled reaching task. In addition to SWS following training, reactivation occurred in REM, primarily during the pre-task rest period, and REM and SWS reactivation occurred on the same day in rats that acquired the skill rapidly. Both pre-task REM and post-task SWS activation were coordinated with muscle activity during sleep, suggesting a functional role for reactivation in skill learning. Our results provide the first demonstration that reactivation in REM sleep occurs during motor skill learning and that coordinated reactivation in both sleep states on the same day, although at different times, is beneficial for skill learning. This article is part of the Theo Murphy meeting issue ‘Memory reactivation: replaying events past, present and future’. |
| Databáze: | OpenAIRE |
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