Development and Characterization of Novel Biopolymer Derived from Abelmoschus esculentus L. Extract and Its Antidiabetic Potential

Autor: Eyad Alshammari, Khalid Mehmood, Mohd Adnan, Jerold C. Alcantara, Mushtaq Ahmad Khan, Syed Amir Ashraf, Nagat Elzein Eltoum, Abd Elmoneim O. Elkhalifa, Amir Mahgoub Awadelkareem
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Potassium
Sodium
α-amylase activity
Pharmaceutical Science
chemistry.chemical_element
Organic chemistry
02 engineering and technology
okra polysaccharides
engineering.material
Polysaccharide
Article
Antioxidants
Analytical Chemistry
03 medical and health sciences
Plant Mucilage
Nutraceutical
Biopolymers
QD241-441
Abelmoschus
Polysaccharides
biopolymer
Drug Discovery
Spectroscopy
Fourier Transform Infrared
Hypoglycemic Agents
Food science
Physical and Theoretical Chemistry
Solubility
030304 developmental biology
chemistry.chemical_classification
nutraceuticals
0303 health sciences
biology
α-glucosidase activity
Plant Extracts
okra mucilage
alpha-Glucosidases
021001 nanoscience & nanotechnology
biology.organism_classification
chemistry
Mucilage
antidiabetic activity
Chemistry (miscellaneous)
Dietary Supplements
engineering
Molecular Medicine
Biopolymer
alpha-Amylases
0210 nano-technology
Zdroj: Molecules, Vol 26, Iss 3609, p 3609 (2021)
Molecules
Volume 26
Issue 12
ISSN: 1420-3049
Popis: Abelmoschus esculentus (Okra) is an important vegetable crop, widely cultivated around the world due to its high nutritional significance along with several health benefits. Different parts of okra including its mucilage have been currently studied for its role in various therapeutic applications. Therefore, we aimed to develop and characterize the okra mucilage biopolymer (OMB) for its physicochemical properties as well as to evaluate its in vitro antidiabetic activity. The characterization of OMB using Fourier-transform infrared spectroscopy (FT-IR) revealed that okra mucilage containing polysaccharides lies in the bandwidth of 3279 and 1030 cm−1, which constitutes the fingerprint region of the spectrum. In addition, physicochemical parameters such as percentage yield, percentage solubility, and swelling index were found to be 2.66%, 96.9%, and 5, respectively. A mineral analysis of newly developed biopolymers showed a substantial amount of calcium (412 mg/100 g), potassium (418 mg/100 g), phosphorus (60 mg/100 g), iron (47 mg/100 g), zinc (16 mg/100 g), and sodium (9 mg/100 g). The significant antidiabetic potential of OMB was demonstrated using α-amylase and α-glucosidase enzyme inhibitory assay. Further investigations are required to explore the newly developed biopolymer for its toxicity, efficacy, and its possible utilization in food, nutraceutical, as well as pharmaceutical industries.
Databáze: OpenAIRE
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