Assessment of Interobserver Reliability of Nephrologist Examination of Urine Sediment
| Autor: | Ragnar Palsson, James E. Novak, Mark A. Perazella, Melanie P. Hoenig, Sushrut S. Waikar, Mia R. Colona, Andrew L. Lundquist |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty Concordance Urine Urinalysis Nephrologists Internal medicine Biopsy Medicine Humans Prospective Studies Prospective cohort study Aged Original Investigation Observer Variation medicine.diagnostic_test business.industry Research Reproducibility of Results General Medicine Dipstick Middle Aged medicine.disease Online Only Female Renal biopsy business Kidney disease |
| Zdroj: | JAMA Network Open |
| ISSN: | 2574-3805 |
| Popis: | Key Points Question What is the interobserver reliability among practicing nephrologists when interpreting urine sediment findings? Findings In this diagnostic study, 14 nephrologists provided 1064 interpretations of images of urine sediment findings. Agreement could be classified as slight, fair, moderate, substantial, or almost perfect. The interobserver reliability of urine sediment findings is mostly moderate to substantial but varies widely. Meaning Results of this study suggest that efforts to decrease variability in urine sediment interpretations may help increase the yield of this widely used test in medicine. Importance Urine sediment microscopy is commonly performed during the evaluation of kidney disease. Interobserver reliability of nephrologists’ urine sediment examination has not been well studied. Objective Assess interobserver reliability of the urine sediment examination. Design, Setting, and Participants In this diagnostic test study, urine samples were prospectively collected from a convenience sample of adult patients from an academic hospital in the United States undergoing kidney biopsy from July 11, 2018, to March 20, 2019. Digital images and videos of urine sediment findings were captured using a bright-field microscope. These images and videos along with urine dipstick results were incorporated in online surveys and sent to expert nephrologists at 15 US teaching hospitals. They were asked to identify individual sediment findings and the most likely underlying disease process. Exposures Urine dipstick results and urine sediment images from patients undergoing native kidney biopsy. Main Outcomes and Measures Interobserver reliability of urine sediment microscopy findings estimated by overall percent agreement and Fleiss κ coefficients. Secondary outcomes included concordance of diagnoses suspected by nephrologists with corresponding kidney biopsy results. Results In total, 10 surveys from 10 patients containing 76 study questions on individual features were sent to 21 nephrologists, 14 (67%) of whom completed them all. Their combined 1064 responses were analyzed. Overall percent agreement for casts was an estimated 59% (95% CI, 50%-69%), κ = 0.52 (95% CI, 0.42-0.62). For other sediment findings, overall percent agreement was an estimated 69% (95% CI, 61%-77%), κ = 0.65 (95% CI, 0.56-0.73). The κ estimates ranged from 0.13 (95% CI, 0.10-0.17) for mixed cellular casts to 0.90 (95% CI, 0.87-0.94) for squamous epithelial cells. Conclusions and Relevance In this study, substantial variability occurred in the interpretation of urine sediment findings, even among expert nephrologists. Educational or technological innovations may help improve the urine sediment as a diagnostic tool. This diagnostic study assesses interobserver reliability of nephrologist examination of urine sediment using high-resolution digital images and videos of the urine sediment of patients across the US undergoing kidney biopsy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|