Cardiovascular event rates increase after each recurrence and associate with poor statin adherence
| Autor: | Susanne Bergius, Mariann I. Lassenius, Julia Perttilä, Mikko Pietilä, Iiro Toppila, K.E. Juhani Airaksinen |
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| Rok vydání: | 2019 |
| Předmět: |
Ldl cholesterol
Cardiovascular event Adult medicine.medical_specialty Statin Epidemiology business.industry medicine.drug_class Cholesterol LDL Risk Assessment Medication Adherence Clinical Practice Cardiovascular prevention Cardiovascular Diseases Risk Factors Internal medicine medicine LDL Cholesterol Lipoproteins Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine business Retrospective Studies |
| Zdroj: | European journal of preventive cardiology. 28(8) |
| ISSN: | 2047-4881 |
| Popis: | Aims The study evaluated the quality of cardiovascular prevention in real-world clinical practice. The recurrence of up to five cardiovascular events was assessed, as data on recurrence beyond the first event and interindividual variations in event rates past the second event have been sparse. Low-density lipoprotein cholesterol concentrations and lipid-lowering therapy use were investigated. Methods This retrospective register-based study included adult patients with an incident cardiovascular event between 2004 and 2016 treated in the hospital district of southwest Finland. Patients were followed for consecutive cardiovascular events or cardiovascular death, low-density lipoprotein cholesterol and statin purchases. The timing of event recurrence was evaluated, and predictive factors were assessed. Results A wide interindividual variation in cardiovascular event recurrence was observed, each additional event caused an increased risk, the median time of recurrence decreased from 7 to one year for the second and fifth event. Event rates increased correspondingly from 12 to 43/100 patient-years and were most pronounced in the first years following the previous event. The low-density lipoprotein cholesterol goal ( Conclusion The study provides new perspectives on individual risk assessment showing that event rates are not stable for all patients but increase 1.2–1.9-fold per consecutive event. The underuse of statins and poor adherence support the identification of these patients for intensified multifactorial preventive measures. |
| Databáze: | OpenAIRE |
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