The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate
| Autor: | Oguzhan Yarali, Ozan Kuduban, Muhammed Recai Mazlumoglu, Osman Kukula, Ertugrul Erhan, Nihal Cetin, Murat Cankaya, Selma Denktas Kuduban, Ferda Keskin Cimen |
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| Přispěvatelé: | OMÜ |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Interleukin-1beta Treatment outcome Lower lip Pharmacology Synthetic drugs Oral mucositis 03 medical and health sciences 0302 clinical medicine Tongue stomatognathic system Malondialdehyde Hippophae Mucositis Animals Medicine General Dentistry Stomatitis biology Plant Extracts Tumor Necrosis Factor-alpha business.industry Hippophae rhamnoides Reproducibility of Results Cheek biology.organism_classification medicine.disease Lip Surgery Rats lcsh:RK1-715 stomatognathic diseases Treatment Outcome 030104 developmental biology medicine.anatomical_structure Methotrexate 030220 oncology & carcinogenesis lcsh:Dentistry Blood Vessels Folic Acid Antagonists Original Article Gene expression business medicine.drug |
| Zdroj: | Journal of Applied Oral Science v.24 n.5 2016 Journal of applied oral science Universidade de São Paulo (USP) instacron:USP Journal of Applied Oral Science, Volume: 24, Issue: 5, Pages: 423-430, Published: OCT 2016 Journal of Applied Oral Science, Vol 24, Iss 5, Pp 423-430 Journal of Applied Oral Science |
| Popis: | Mazlumoglu, Muhammet Recai/0000-0003-2362-0862 WOS: 000387779600002 PubMed: 27812611 Objective: To investigate the effect of HRE (Hippophae rhamnoides extract) on oral Linnucositis induced in rats with MTX. Material and Methods: Experimental animals were divided into groups as healthy (HG), HRE+MTX (HMTX), and control group, which received MTX (MTXC). HMTX group received 50 mg/kg HRE while MTXC and HG groups received equivolume distilled water with gavage once a day. After one hour of HRE and distilled water administration, HMTX and MTXC groups received a single dose of oral MTX 5 mg/ kg. This procedure was repeated for one month. Results: The levels of MDA, IL-1 beta, and TNF-alpha were found to be significantly higher in the cheek, lower lip, and tongue tissue of the animals receiving MTX, compared with HG and HMTX groups; however, these parameters were lower in the cheek and low lip tissue, and a milder damage ocurred in these tissues, compared with the tongue tissue in MTXC group. No histopathologic damage was observed in the cheek, lower lip, and tongue tissues of the rats treated with HRE. Conclusion: This findings indicate that HRE as a natural product is an important advantage compared with synthetic drugs for prophylaxis of oral mucositis developed due to MTX. |
| Databáze: | OpenAIRE |
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