Dominance reversals and the maintenance of genetic variation
| Autor: | Grieshop, Karl, Ho, Eddie K. H., Kasimatis, Katja R. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Popis: | The last decade has seen increasing theoretical and empirical support for beneficial reversals of dominance enabling selection to maintain genetic variation for fitness through various forms of genetic tradeoffs. Dominance reversals are characterized by the beneficial allele for a given context (e.g., niche, time, trait or sex) being dominant in that context. This context-dependence at least partially mitigates the fitness consequence of heterozygotes carrying one of the 'wrong' alleles for their context and can result in balancing selection that maintains both alleles. Despite being dismissed by some early on, dominance reversals are an inevitable outcome of antagonistic selection under reasonable assumptions, and mounting empirical evidence largely supports this theory. Here we review the theory and empirical evidence for beneficial reversals of dominance. Along the way, we identify some areas in need of further research and development, point out some complications with contemporary approaches for detecting genetic tradeoffs, and highlight methods that leverage signatures of dominance reversal toward identifying genetic tradeoffs. There is ample scope for the development of new empirical methods that focus on signatures of dominance reversal, and there is likely also an abundance of data that are ripe for reanalysis. A greater focus on this topic would expand our understanding of the maintenance of genetic variance and local adaptation. Review paper with some original theory, 3 Figures, 1 table, and Supporting Information (including 10 Figures and 2 tables) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|