Emerging Biomimetic Materials for Studying Tumor and Immune Cell Behavior
| Autor: | Logan A Northcutt, Marjan Rafat, Alejandra Suarez-Arnedo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Integrins
Cell Culture Techniques Biomedical Engineering Cell Communication Biology Article Metastasis Extracellular matrix Immune system Biomimetic Materials Neoplasms Spheroids Cellular Tumor Microenvironment medicine Animals Humans Epithelial–mesenchymal transition Integrin binding Tumor microenvironment Macrophages Cancer Fibroblasts medicine.disease Extracellular Matrix Cell biology Organoids Cancer cell |
| Zdroj: | Ann Biomed Eng |
| ISSN: | 1573-9686 0090-6964 |
| DOI: | 10.1007/s10439-019-02384-0 |
| Popis: | Cancer is one of the leading causes of death both in the United States and worldwide. The dynamic microenvironment in which tumors grow consists of fibroblasts, immune cells, extracellular matrix (ECM), and cytokines that enable progression and metastasis. Novel biomaterials that mimic these complex surroundings give insight into the biological, chemical, and physical environment that cause cancer cells to metastasize and invade in to other tissues. Two-dimensional (2D) cultures are useful for gaining limited information about cancer cell behavior; however, they do not accurately represent the environments that cells experience in vivo. Recent advances in the design and tunability of diverse three-dimensional (3D) biomaterials complement biological knowledge and allow for improved recapitulation of in vivo conditions. Understanding cell–ECM and cell–cell interactions that facilitate tumor survival will accelerate the design of more effective therapies. This review discusses innovative materials currently being used to study tumor and immune cell behavior and interactions, including materials that mimic the ECM composition, mechanical stiffness, and integrin binding sites of the tumor microenvironment. |
| Databáze: | OpenAIRE |
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