The Timing of Sensory-Guided Behavioral Response is Represented in the Mouse Primary Somatosensory Cortex
| Autor: | Ingrid Bureau, Melissa A. Erlandson, Sabria Lagoun, Jeremy Camon, Sandrine Hugues, David Robbe, Emna Marouane |
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| Přispěvatelé: | Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université] ( INMED - INSERM U1249 ), Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Agence Nationale de la Recherche (Grant number ANR-11-BSV4-0013) and the Human Frontier Science Program (Grant number CDA—0041/2007-C). MAE’s thesis was supported by the Excellence Initiative of Aix-Marseille University—A*MIDEX (ICN PhD program). Current affiliation of J. Camon is UPRES EA 2647 |USC INRA 1330, University of Angers (Angers, France)., ANR-11-BSV4-0013,CorteXcell,Les mécanismes corticaux de l'apprentissage associatif et de ses troubles dans le syndrome de l'X Fragile ( 2011 ), Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université] (INMED - INSERM U1249), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bureau, Ingrid, Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU) |
| Rok vydání: | 2018 |
| Předmět: |
Male
Time Factors [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Cognitive Neuroscience media_common.quotation_subject Decision Making Sensory system Stimulation Biology Stimulus (physiology) Somatosensory system 050105 experimental psychology Mice 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Reward Perception medicine Animals Premovement neuronal activity 0501 psychology and cognitive sciences media_common Afferent Pathways learning 05 social sciences [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Somatosensory Cortex Barrel cortex perceptual decision Mice Inbred C57BL barrel medicine.anatomical_structure Vibrissae plasticity [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] circuit Cortical column Neuroscience Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Cerebral Cortex Cerebral Cortex, Oxford University Press (OUP), 2018, Epub ahead of print. 〈10.1093/cercor/bhy169〉 Cerebral Cortex, Oxford University Press (OUP), In press, ⟨10.1093/cercor/bhy169⟩ |
| ISSN: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhy169 |
| Popis: | Whisker-guided decision making in mice is thought to critically depend on information processing occurring in the primary somatosensory cortex. However, it is not clear if neuronal activity in this “early” sensory region contains information about the timing and speed of motor response. To address this question we designed a new task in which freely moving mice learned to associate a whisker stimulus to reward delivery. The task was tailored in such a way that a wide range of delays between whisker stimulation and reward collection were observed due to differences of motivation and perception. After training, mice were anesthetized and neuronal responses evoked by stimulating trained and untrained whiskers were recorded across several cortical columns of barrel cortex. We found a strong correlation between the delay of the mouse behavioral response and the timing of multiunit activity evoked by the trained whisker, outside its principal cortical column, in layers 4 and 5A but not in layer 2/3. Circuit mapping ex vivo revealed this effect was associated with a weakening of layer 4 to layer 2/3 projection. We conclude that the processes controlling the propagation of key sensory inputs to naive cortical columns and the timing of sensory-guided action are linked. |
| Databáze: | OpenAIRE |
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