Human Lung Tissue Transcriptome
| Autor: | David C. Nickle, Maarten van den Berge, Tommaso A. Dragani, Matteo Incarbone, Chiara E. Cotroneo, Peter D. Paré, Lorenzo Rosso, Emilie Lavoie-Charland, Yohan Bossé, Matteo Dugo, Francesca Colombo, Luigi Santambrogio |
|---|---|
| Přispěvatelé: | Groningen Research Institute for Asthma and COPD (GRIAC) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Pathology Aging BLOOD Microarray Transcription Genetic Physiology lcsh:Medicine Lung and Intrathoracic Tumors Transcriptome Adenocarcinomas Gene expression Medicine and Health Sciences lcsh:Science Lung X chromosome GENE-EXPRESSION Sex Characteristics Multidisciplinary Sex Chromosomes Adenocarcinoma of the Lung Chromosome Biology SIGNATURE Photodermatology and Skin Aging X Chromosomes Middle Aged medicine.anatomical_structure Oncology SURVIVAL Adenocarcinoma Female Sex characteristics Research Article medicine.medical_specialty PIPELINE Surgical and Invasive Medical Procedures Dermatology Biology lung parenchyma Carcinomas Chromosomes 03 medical and health sciences MICROARRAY medicine Genetics Humans sex Gene Regulation X-INACTIVATION Gene METAANALYSIS lcsh:R Biology and Life Sciences Cancers and Neoplasms Cell Biology PROFILES medicine.disease EVOLUTION 030104 developmental biology age inflammation gene expression lcsh:Q Secondary Lung Tumors |
| Zdroj: | PLoS ONE, 11(11):e0167460. PUBLIC LIBRARY SCIENCE PLoS ONE, Vol 11, Iss 11, p e0167460 (2016) PloS one 11 (2016). doi:10.1371/journal.pone.0167460 info:cnr-pdr/source/autori:Dugo, Matteo; Cotroneo, Chiara E.; Lavoie-Charland, Emilie; Incarbone, Matteo; Santambrogio, Luigi; Rosso, Lorenzo; Van Den Berge, Maarten; Nickle, David; Paré, Peter D.; Bossé, Yohan; Dragani, Tommaso A.; Colombo, Francesca/titolo:Human lung tissue transcriptome: Influence of sex and age/doi:10.1371%2Fjournal.pone.0167460/rivista:PloS one/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume:11 PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | BackgroundSex and age strongly influence the pathophysiology of human lungs, but scarce information is available about their effects on pulmonary gene expression.MethodsWe followed a discovery-validation strategy to identify sex-and age-related transcriptional differences in lung.ResultsWe identified transcriptional profiles significantly associated with sex (215 genes; FDR ConclusionsGene expression in non-tumor lung tissue is modulated by both sex and age. These findings represent a validated starting point for research on the molecular mechanisms underlying the observed differences in the course of lung diseases among men and women of different ages. |
| Databáze: | OpenAIRE |
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