Baseline predictors of central aortic blood pressure: a PEAR substudy
| Autor: | Eric Boerwinkle, Rebecca F Rosenwasser, John G. Gums, Julie A. Johnson, Xuerong Wen, Benjamin J Epstein, Steven M. Smith, Arlene B. Chapman, Wilmer W. Nichols, Niren K Shah, Yan Gong |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Diastole Essential hypertension Article Young Adult Vascular Stiffness Internal medicine Heart rate Internal Medicine medicine Humans Arterial Pressure cardiovascular diseases Prospective Studies Prospective cohort study Antihypertensive Agents Aorta Aged business.industry Middle Aged medicine.disease Prognosis Surgery Pulse pressure Peripheral Blood pressure Treatment Outcome Hypertension Cardiology Aortic pressure Female Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology Follow-Up Studies |
| Zdroj: | Journal of the American Society of Hypertension : JASH. 8(3) |
| ISSN: | 1878-7436 |
| Popis: | Elevated central systolic blood pressure (BP) increases the risk of cardiovascular events and appears superior to peripheral BP for long term risk prediction. The objective of this study was to identify demographic and clinical factors associated with central pressures in patients with uncomplicated hypertension. We prospectively examined peripheral BP, central aortic BP, and arterial wall properties and wave reflection in 57 subjects with uncomplicated essential hypertension in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) Study. Significant predictors of central SBP included height, smoking status, heart rate (HR), and peripheral systolic BP (SBP), while central diastolic BP (DBP) was explained by peripheral DBP and HR. These variables accounted for nearly all of the variability in central SBP and central DBP (R 2 = 0.94 and R 2 = 0.98, respectively). Central pulse pressure variability was largely explained by gender, ex-smoking status, HR, peripheral SBP, and peripheral DBP (R 2 = 0.94). Central augmented pressure had a direct relationship with smoking status, peripheral SBP, and duration of hypertension, whereas it was indirectly related to height, HR, and peripheral DBP. Easily obtainable demographic and clinical factors are associated with central pressures in essential hypertensive persons. These relationships should be considered in future studies to improve assessment of BP to reduce cardiovascular risk and mortality. |
| Databáze: | OpenAIRE |
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